MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma
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MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma. / Ronald, J A; Katzenberg, R; Nielsen, Carsten Haagen; Jae, H J; Hofmann, L V; Gambhir, S S.
I: Gene Therapy, Bind 20, 30.05.2013, s. 1006-1013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma
AU - Ronald, J A
AU - Katzenberg, R
AU - Nielsen, Carsten Haagen
AU - Jae, H J
AU - Hofmann, L V
AU - Gambhir, S S
PY - 2013/5/30
Y1 - 2013/5/30
N2 - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P
AB - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P
U2 - 10.1038/gt.2013.24
DO - 10.1038/gt.2013.24
M3 - Journal article
C2 - 23719066
VL - 20
SP - 1006
EP - 1013
JO - Gene Therapy
JF - Gene Therapy
SN - 0969-7128
ER -
ID: 47315946