Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis

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Standard

Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis. / Sabbah, Muhammad; Olsen, Niels Thue; Minkkinen, Mikko; Holmvang, Lene; Tilsted, Hans Henrik; Pedersen, Frants; Joshi, Francis R.; Ahtarovski, Kiril; Sørensen, Rikke; Linde, Jesper James; Søndergaard, Lars; Pijls, Nico; Lønborg, Jacob; Engstrøm, Thomas.

I: Journal of the American Heart Association, Bind 11, Nr. 9, e025381, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sabbah, M, Olsen, NT, Minkkinen, M, Holmvang, L, Tilsted, HH, Pedersen, F, Joshi, FR, Ahtarovski, K, Sørensen, R, Linde, JJ, Søndergaard, L, Pijls, N, Lønborg, J & Engstrøm, T 2022, 'Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis', Journal of the American Heart Association, bind 11, nr. 9, e025381. https://doi.org/10.1161/JAHA.122.025381

APA

Sabbah, M., Olsen, N. T., Minkkinen, M., Holmvang, L., Tilsted, H. H., Pedersen, F., Joshi, F. R., Ahtarovski, K., Sørensen, R., Linde, J. J., Søndergaard, L., Pijls, N., Lønborg, J., & Engstrøm, T. (2022). Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis. Journal of the American Heart Association, 11(9), [e025381]. https://doi.org/10.1161/JAHA.122.025381

Vancouver

Sabbah M, Olsen NT, Minkkinen M, Holmvang L, Tilsted HH, Pedersen F o.a. Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis. Journal of the American Heart Association. 2022;11(9). e025381. https://doi.org/10.1161/JAHA.122.025381

Author

Sabbah, Muhammad ; Olsen, Niels Thue ; Minkkinen, Mikko ; Holmvang, Lene ; Tilsted, Hans Henrik ; Pedersen, Frants ; Joshi, Francis R. ; Ahtarovski, Kiril ; Sørensen, Rikke ; Linde, Jesper James ; Søndergaard, Lars ; Pijls, Nico ; Lønborg, Jacob ; Engstrøm, Thomas. / Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis. I: Journal of the American Heart Association. 2022 ; Bind 11, Nr. 9.

Bibtex

@article{acaf886f939240dcb3ae2a428cd7e79a,

title = "Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis",

abstract = "BACKGROUND: Left ventricular hypertrophy (LVH) has often been supposed to be associated with abnormal myocardial blood flow and resistance. The aim of this study was to evaluate and quantify the physiological and pathological changes in myocar-dial blood flow and microcirculatory resistance in patients with and without LVH attributable to severe aortic stenosis. METHODS AND RESULTS: Absolute coronary blood flow and microvascular resistance were measured using a novel technique with continuous thermodilution and infusion of saline. In addition, myocardial mass was assessed with cardiac magnetic resonance imaging. Fifty-three patients with aortic valve stenosis were enrolled in the study. In 32 patients with LVH, hyper-emic blood flow per gram of tissue was significantly decreased compared with 21 patients without LVH (1.26±0.48 versus 1.66±0.65 mL·min−1·g −1; P=0.018), whereas minimal resistance indexed for left ventricular mass was significantly increased in patients with LVH (63 [47– 82] versus 43 [35– 63] Wood Units·kg; P=0.014). CONCLUSIONS: Patients with LVH attributable to severe aortic stenosis had lower hyperemic blood flow per gram of myocar-dium and higher minimal myocardial resistance compared with patients without LVH.",

keywords = "aortic stenosis, cardiac magnetic resonance imaging, coronary flow, left ventricular hypertrophy, microvascular function, thermodilution",

author = "Muhammad Sabbah and Olsen, {Niels Thue} and Mikko Minkkinen and Lene Holmvang and Tilsted, {Hans Henrik} and Frants Pedersen and Joshi, {Francis R.} and Kiril Ahtarovski and Rikke S{\o}rensen and Linde, {Jesper James} and Lars S{\o}ndergaard and Nico Pijls and Jacob L{\o}nborg and Thomas Engstr{\o}m",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",

year = "2022",

doi = "10.1161/JAHA.122.025381",

language = "English",

volume = "11",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley-Blackwell",

number = "9",

}

RIS

TY - JOUR

T1 - Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis

AU - Sabbah, Muhammad

AU - Olsen, Niels Thue

AU - Minkkinen, Mikko

AU - Holmvang, Lene

AU - Tilsted, Hans Henrik

AU - Pedersen, Frants

AU - Joshi, Francis R.

AU - Ahtarovski, Kiril

AU - Sørensen, Rikke

AU - Linde, Jesper James

AU - Søndergaard, Lars

AU - Pijls, Nico

AU - Lønborg, Jacob

AU - Engstrøm, Thomas

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Left ventricular hypertrophy (LVH) has often been supposed to be associated with abnormal myocardial blood flow and resistance. The aim of this study was to evaluate and quantify the physiological and pathological changes in myocar-dial blood flow and microcirculatory resistance in patients with and without LVH attributable to severe aortic stenosis. METHODS AND RESULTS: Absolute coronary blood flow and microvascular resistance were measured using a novel technique with continuous thermodilution and infusion of saline. In addition, myocardial mass was assessed with cardiac magnetic resonance imaging. Fifty-three patients with aortic valve stenosis were enrolled in the study. In 32 patients with LVH, hyper-emic blood flow per gram of tissue was significantly decreased compared with 21 patients without LVH (1.26±0.48 versus 1.66±0.65 mL·min−1·g −1; P=0.018), whereas minimal resistance indexed for left ventricular mass was significantly increased in patients with LVH (63 [47– 82] versus 43 [35– 63] Wood Units·kg; P=0.014). CONCLUSIONS: Patients with LVH attributable to severe aortic stenosis had lower hyperemic blood flow per gram of myocar-dium and higher minimal myocardial resistance compared with patients without LVH.

AB - BACKGROUND: Left ventricular hypertrophy (LVH) has often been supposed to be associated with abnormal myocardial blood flow and resistance. The aim of this study was to evaluate and quantify the physiological and pathological changes in myocar-dial blood flow and microcirculatory resistance in patients with and without LVH attributable to severe aortic stenosis. METHODS AND RESULTS: Absolute coronary blood flow and microvascular resistance were measured using a novel technique with continuous thermodilution and infusion of saline. In addition, myocardial mass was assessed with cardiac magnetic resonance imaging. Fifty-three patients with aortic valve stenosis were enrolled in the study. In 32 patients with LVH, hyper-emic blood flow per gram of tissue was significantly decreased compared with 21 patients without LVH (1.26±0.48 versus 1.66±0.65 mL·min−1·g −1; P=0.018), whereas minimal resistance indexed for left ventricular mass was significantly increased in patients with LVH (63 [47– 82] versus 43 [35– 63] Wood Units·kg; P=0.014). CONCLUSIONS: Patients with LVH attributable to severe aortic stenosis had lower hyperemic blood flow per gram of myocar-dium and higher minimal myocardial resistance compared with patients without LVH.

KW - aortic stenosis

KW - cardiac magnetic resonance imaging

KW - coronary flow

KW - left ventricular hypertrophy

KW - microvascular function

KW - thermodilution

U2 - 10.1161/JAHA.122.025381

DO - 10.1161/JAHA.122.025381

M3 - Journal article

C2 - 35470693

AN - SCOPUS:85129781588

VL - 11

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 9

M1 - e025381

ER -

ID: 308332861