Methylphenidate misuse in adult patients and the impact of therapeutic use
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Methylphenidate misuse in adult patients and the impact of therapeutic use. / Jensen, L S; Pagsberg, Anne Katrine; Dalhoff, Kim.
I: Human & Experimental Toxicology, Bind 34, Nr. 5, 2015, s. 460-467.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Methylphenidate misuse in adult patients and the impact of therapeutic use
AU - Jensen, L S
AU - Pagsberg, Anne Katrine
AU - Dalhoff, Kim
N1 - © The Author(s) 2014.
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored.METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH.RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal attempt and in 40% by recreational use (based on 375 cases). Exposure was dominated by one trade name and exposure incidence correlated significantly with sales ( p = 0.001) and prevalence of MPH-treated patients ( p = 0.0008).CONCLUSIONS: The increase in MPH exposures parallels the prescription rates (particularly Ritalin(®)/Ritalin(®) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use.
AB - OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored.METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH.RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal attempt and in 40% by recreational use (based on 375 cases). Exposure was dominated by one trade name and exposure incidence correlated significantly with sales ( p = 0.001) and prevalence of MPH-treated patients ( p = 0.0008).CONCLUSIONS: The increase in MPH exposures parallels the prescription rates (particularly Ritalin(®)/Ritalin(®) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use.
U2 - 10.1177/0960327114543935
DO - 10.1177/0960327114543935
M3 - Journal article
C2 - 25062974
VL - 34
SP - 460
EP - 467
JO - Human and Experimental Toxicology
JF - Human and Experimental Toxicology
SN - 0960-3271
IS - 5
ER -
ID: 137746815