Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Eicosanoids are a family of bioactive compounds derived from arachidonic acid (AA) that play pivotal roles in physiology and disease, including inflammatory conditions of multiple organ systems. The biosynthesis of eicosanoids requires a series of catalytic steps that are controlled by designated enzymes, which can be regulated by inflammatory and stress signals via transcriptional and translational mechanisms. In the past decades, evidence have emerged indicating that G-protein coupled receptors (GPCRs) can sense extracellular metabolites, and regulate inflammatory responses including eicosanoid production. This review focuses on the recent advances of metabolite GPCRs research, their role in regulation of eicosanoid biosynthesis, and the link to pathophysiological conditions.
Originalsprog | Engelsk |
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Artikelnummer | 115208 |
Tidsskrift | Biochemical Pharmacology |
Vol/bind | 204 |
Antal sider | 7 |
ISSN | 0006-2952 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This study was supported by the Swedish Research Council (Grant 2018-02818), immunometabolism grants (NNF15CC0018346 and 0064142) and Karolinska Institutet. XT was supported by the Konsul Th C Berghs Foundation (Grant 2356).
Publisher Copyright:
© 2022
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