Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Kliemann, Nathalie; Ammar, Romain Ould; Biessy, Carine; Gicquiau, Audrey; Katzke, Verena; Kaaks, Rudolf; Tjonneland, Anne; Olsen, Anja; Sanchez, Maria-Jose; Crous-Bou, Marta; Pasanisi, Fabrizio; Tin, Sandar Tin; Perez-Cornago, Aurora; Aune, Dagfinn; Christakoudi, Sofia; Heath, Alicia K.; Colorado-Yohar, Sandra M.; Grioni, Sara; Skeie, Guri; Sartor, Hanna; Idahl, Annika; Rylander, Charlotta; May, Anne M.; Weiderpass, Elisabete; Freisling, Heinz; Playdon, Mary C.; Rinaldi, Sabina; Murphy, Neil; Huybrechts, Inge; Dossus, Laure; Gunter, Marc J.

I: Cancer Epidemiology, Biomarkers & Prevention, Bind 31, Nr. 7, 2022, s. 1359-1367.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kliemann, N, Ammar, RO, Biessy, C, Gicquiau, A, Katzke, V, Kaaks, R, Tjonneland, A, Olsen, A, Sanchez, M-J, Crous-Bou, M, Pasanisi, F, Tin, ST, Perez-Cornago, A, Aune, D, Christakoudi, S, Heath, AK, Colorado-Yohar, SM, Grioni, S, Skeie, G, Sartor, H, Idahl, A, Rylander, C, May, AM, Weiderpass, E, Freisling, H, Playdon, MC, Rinaldi, S, Murphy, N, Huybrechts, I, Dossus, L & Gunter, MJ 2022, 'Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Cancer Epidemiology, Biomarkers & Prevention, bind 31, nr. 7, s. 1359-1367. https://doi.org/10.1158/1055-9965.EPI-22-0160

APA

Kliemann, N., Ammar, R. O., Biessy, C., Gicquiau, A., Katzke, V., Kaaks, R., Tjonneland, A., Olsen, A., Sanchez, M-J., Crous-Bou, M., Pasanisi, F., Tin, S. T., Perez-Cornago, A., Aune, D., Christakoudi, S., Heath, A. K., Colorado-Yohar, S. M., Grioni, S., Skeie, G., ... Gunter, M. J. (2022). Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology, Biomarkers & Prevention, 31(7), 1359-1367. https://doi.org/10.1158/1055-9965.EPI-22-0160

Vancouver

Kliemann N, Ammar RO, Biessy C, Gicquiau A, Katzke V, Kaaks R o.a. Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology, Biomarkers & Prevention. 2022;31(7):1359-1367. https://doi.org/10.1158/1055-9965.EPI-22-0160

Author

Kliemann, Nathalie ; Ammar, Romain Ould ; Biessy, Carine ; Gicquiau, Audrey ; Katzke, Verena ; Kaaks, Rudolf ; Tjonneland, Anne ; Olsen, Anja ; Sanchez, Maria-Jose ; Crous-Bou, Marta ; Pasanisi, Fabrizio ; Tin, Sandar Tin ; Perez-Cornago, Aurora ; Aune, Dagfinn ; Christakoudi, Sofia ; Heath, Alicia K. ; Colorado-Yohar, Sandra M. ; Grioni, Sara ; Skeie, Guri ; Sartor, Hanna ; Idahl, Annika ; Rylander, Charlotta ; May, Anne M. ; Weiderpass, Elisabete ; Freisling, Heinz ; Playdon, Mary C. ; Rinaldi, Sabina ; Murphy, Neil ; Huybrechts, Inge ; Dossus, Laure ; Gunter, Marc J. / Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). I: Cancer Epidemiology, Biomarkers & Prevention. 2022 ; Bind 31, Nr. 7. s. 1359-1367.

Bibtex

@article{aa39fdcc8659401bba480a80ecb1cd8f,

title = "Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)",

abstract = "Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; < 1st tertile) and metabolically unhealthy (MU; >_1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW); body mass index (BMI)< 25 kg/m2 or waist circumference (WC)< 80 cm or waist-to-hip ratio (WHR)< 0.8) and overweight (OW; BMI >_25 kg/m2 or WC >_80 cm or WHR >_0. 8) status, generating four phenotype groups for each anthropometric measure: (i) MH/NW, (ii) MH/OW, (iii) MU/ NW, and (iv) MU/OW. Results: In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW [ORWC, 1.48; 95% confidence interval (CI), 1.05-2.10 and ORWHR, 1.68; 95% CI, 1.21- 2.35] and MU/OW (ORBMI, 2.38; 95% CI, 1.73-3.27; ORWC, 2.69; 95% CI, 1.92-3.77 and ORWHR, 1.83; 95% CI, 1.32-2.54). MH/OW individuals were also at increased endometrial cancer risk compared with MH/NW individuals (ORWC, 1.94; 95% CI, 1.24-3.04). Conclusions: Women with metabolic dysfunction appear to have higher risk of endometrial cancer regardless of their body size. However, OW status raises endometrial cancer risk even among women with lower insulin levels, suggesting that obesity related pathways are relevant for the development of this cancer beyond insulin. Impact: Classifying women by metabolic health may be of greater utility in identifying those at higher risk for endometrial cancer than anthropometry per se.",

keywords = "INSULIN-RESISTANCE, MASS INDEX, ANTHROPOMETRIC FACTORS, C-PEPTIDE, OBESITY, HEALTH, OVERWEIGHT, ESTROGEN, VALIDITY, GROWTH",

author = "Nathalie Kliemann and Ammar, {Romain Ould} and Carine Biessy and Audrey Gicquiau and Verena Katzke and Rudolf Kaaks and Anne Tjonneland and Anja Olsen and Maria-Jose Sanchez and Marta Crous-Bou and Fabrizio Pasanisi and Tin, {Sandar Tin} and Aurora Perez-Cornago and Dagfinn Aune and Sofia Christakoudi and Heath, {Alicia K.} and Colorado-Yohar, {Sandra M.} and Sara Grioni and Guri Skeie and Hanna Sartor and Annika Idahl and Charlotta Rylander and May, {Anne M.} and Elisabete Weiderpass and Heinz Freisling and Playdon, {Mary C.} and Sabina Rinaldi and Neil Murphy and Inge Huybrechts and Laure Dossus and Gunter, {Marc J.}",

year = "2022",

doi = "10.1158/1055-9965.EPI-22-0160",

language = "English",

volume = "31",

pages = "1359--1367",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research (A A C R)",

number = "7",

}

RIS

TY - JOUR

T1 - Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Kliemann, Nathalie

AU - Ammar, Romain Ould

AU - Biessy, Carine

AU - Gicquiau, Audrey

AU - Katzke, Verena

AU - Kaaks, Rudolf

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Sanchez, Maria-Jose

AU - Crous-Bou, Marta

AU - Pasanisi, Fabrizio

AU - Tin, Sandar Tin

AU - Perez-Cornago, Aurora

AU - Aune, Dagfinn

AU - Christakoudi, Sofia

AU - Heath, Alicia K.

AU - Colorado-Yohar, Sandra M.

AU - Grioni, Sara

AU - Skeie, Guri

AU - Sartor, Hanna

AU - Idahl, Annika

AU - Rylander, Charlotta

AU - May, Anne M.

AU - Weiderpass, Elisabete

AU - Freisling, Heinz

AU - Playdon, Mary C.

AU - Rinaldi, Sabina

AU - Murphy, Neil

AU - Huybrechts, Inge

AU - Dossus, Laure

AU - Gunter, Marc J.

PY - 2022

Y1 - 2022

N2 - Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; < 1st tertile) and metabolically unhealthy (MU; >_1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW); body mass index (BMI)< 25 kg/m2 or waist circumference (WC)< 80 cm or waist-to-hip ratio (WHR)< 0.8) and overweight (OW; BMI >_25 kg/m2 or WC >_80 cm or WHR >_0. 8) status, generating four phenotype groups for each anthropometric measure: (i) MH/NW, (ii) MH/OW, (iii) MU/ NW, and (iv) MU/OW. Results: In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW [ORWC, 1.48; 95% confidence interval (CI), 1.05-2.10 and ORWHR, 1.68; 95% CI, 1.21- 2.35] and MU/OW (ORBMI, 2.38; 95% CI, 1.73-3.27; ORWC, 2.69; 95% CI, 1.92-3.77 and ORWHR, 1.83; 95% CI, 1.32-2.54). MH/OW individuals were also at increased endometrial cancer risk compared with MH/NW individuals (ORWC, 1.94; 95% CI, 1.24-3.04). Conclusions: Women with metabolic dysfunction appear to have higher risk of endometrial cancer regardless of their body size. However, OW status raises endometrial cancer risk even among women with lower insulin levels, suggesting that obesity related pathways are relevant for the development of this cancer beyond insulin. Impact: Classifying women by metabolic health may be of greater utility in identifying those at higher risk for endometrial cancer than anthropometry per se.

AB - Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; < 1st tertile) and metabolically unhealthy (MU; >_1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW); body mass index (BMI)< 25 kg/m2 or waist circumference (WC)< 80 cm or waist-to-hip ratio (WHR)< 0.8) and overweight (OW; BMI >_25 kg/m2 or WC >_80 cm or WHR >_0. 8) status, generating four phenotype groups for each anthropometric measure: (i) MH/NW, (ii) MH/OW, (iii) MU/ NW, and (iv) MU/OW. Results: In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW [ORWC, 1.48; 95% confidence interval (CI), 1.05-2.10 and ORWHR, 1.68; 95% CI, 1.21- 2.35] and MU/OW (ORBMI, 2.38; 95% CI, 1.73-3.27; ORWC, 2.69; 95% CI, 1.92-3.77 and ORWHR, 1.83; 95% CI, 1.32-2.54). MH/OW individuals were also at increased endometrial cancer risk compared with MH/NW individuals (ORWC, 1.94; 95% CI, 1.24-3.04). Conclusions: Women with metabolic dysfunction appear to have higher risk of endometrial cancer regardless of their body size. However, OW status raises endometrial cancer risk even among women with lower insulin levels, suggesting that obesity related pathways are relevant for the development of this cancer beyond insulin. Impact: Classifying women by metabolic health may be of greater utility in identifying those at higher risk for endometrial cancer than anthropometry per se.

KW - INSULIN-RESISTANCE

KW - MASS INDEX

KW - ANTHROPOMETRIC FACTORS

KW - C-PEPTIDE

KW - OBESITY

KW - HEALTH

KW - OVERWEIGHT

KW - ESTROGEN

KW - VALIDITY

KW - GROWTH

U2 - 10.1158/1055-9965.EPI-22-0160

DO - 10.1158/1055-9965.EPI-22-0160

M3 - Journal article

C2 - 35437568

VL - 31

SP - 1359

EP - 1367

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 7

ER -

ID: 314896351