Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women
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Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women. / Liang, Liang; Rasmussen, Marie Louise Hee; Piening, Brian; Shen, Xiaotao; Chen, Songjie; Röst, Hannes; Snyder, John K.; Tibshirani, Robert; Skotte, Line; Lee, Norman CY; Contrepois, Kévin; Feenstra, Bjarke; Zackriah, Hanyah; Snyder, Michael; Melbye, Mads.
I: Cell, Bind 181, Nr. 7, 2020, s. 1680-1692.e15.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women
AU - Liang, Liang
AU - Rasmussen, Marie Louise Hee
AU - Piening, Brian
AU - Shen, Xiaotao
AU - Chen, Songjie
AU - Röst, Hannes
AU - Snyder, John K.
AU - Tibshirani, Robert
AU - Skotte, Line
AU - Lee, Norman CY
AU - Contrepois, Kévin
AU - Feenstra, Bjarke
AU - Zackriah, Hanyah
AU - Snyder, Michael
AU - Melbye, Mads
PY - 2020
Y1 - 2020
N2 - Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly changed during pregnancy. Using linear models, we built a metabolic clock with five metabolites that time gestational age in high accordance with ultrasound (R = 0.92). Furthermore, two to three metabolites can identify when labor occurs (time to delivery within two, four, and eight weeks, AUROC ≥ 0.85). Our study represents a weekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for understanding pregnancy with potential clinical utilities.
AB - Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly changed during pregnancy. Using linear models, we built a metabolic clock with five metabolites that time gestational age in high accordance with ultrasound (R = 0.92). Furthermore, two to three metabolites can identify when labor occurs (time to delivery within two, four, and eight weeks, AUROC ≥ 0.85). Our study represents a weekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for understanding pregnancy with potential clinical utilities.
KW - delivery prediction
KW - gestational age
KW - human pregnancy
KW - longitudinal profiling
KW - machine learning
KW - metabolic clock
KW - metabolic pathways
KW - metabolomics
U2 - 10.1016/j.cell.2020.05.002
DO - 10.1016/j.cell.2020.05.002
M3 - Journal article
C2 - 32589958
AN - SCOPUS:85086798738
VL - 181
SP - 1680-1692.e15
JO - Cell
JF - Cell
SN - 0092-8674
IS - 7
ER -
ID: 251023083