Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. / Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H; Steinberg, Stacy; Borck, Guntram; Koiranen, Markku; Quaye, Lydia; Adams, Hieab H H; Lehtimäki, Terho; Sarin, Antti-Pekka; Wedenoja, Juho; Hinds, David A; Buring, Julie E; Schürks, Markus; Ridker, Paul M; Hrafnsdottir, Maria Gudlaug; Stefansson, Hreinn; Ring, Susan M; Hottenga, Jouke-Jan; Penninx, Brenda W J H; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari; Vepsäläinen, Salli; Malik, Rainer; Heath, Andrew C; Madden, Pamela A F; Martin, Nicholas G; Montgomery, Grant W; Christensen, Anne Francke; Hansen, Thomas Folkmann; Werge, Thomas; Olesen, Jes; International Headache Genetics Consortium.
I: Nature Genetics, Bind 48, Nr. 8, 08.2016, s. 856-66.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
AU - Gormley, Padhraig
AU - Anttila, Verneri
AU - Winsvold, Bendik S
AU - Palta, Priit
AU - Esko, Tonu
AU - Pers, Tune H
AU - Farh, Kai-How
AU - Cuenca-Leon, Ester
AU - Muona, Mikko
AU - Furlotte, Nicholas A
AU - Kurth, Tobias
AU - Ingason, Andres
AU - McMahon, George
AU - Ligthart, Lannie
AU - Terwindt, Gisela M
AU - Kallela, Mikko
AU - Freilinger, Tobias M
AU - Ran, Caroline
AU - Gordon, Scott G
AU - Stam, Anine H
AU - Steinberg, Stacy
AU - Borck, Guntram
AU - Koiranen, Markku
AU - Quaye, Lydia
AU - Adams, Hieab H H
AU - Lehtimäki, Terho
AU - Sarin, Antti-Pekka
AU - Wedenoja, Juho
AU - Hinds, David A
AU - Buring, Julie E
AU - Schürks, Markus
AU - Ridker, Paul M
AU - Hrafnsdottir, Maria Gudlaug
AU - Stefansson, Hreinn
AU - Ring, Susan M
AU - Hottenga, Jouke-Jan
AU - Penninx, Brenda W J H
AU - Färkkilä, Markus
AU - Artto, Ville
AU - Kaunisto, Mari
AU - Vepsäläinen, Salli
AU - Malik, Rainer
AU - Heath, Andrew C
AU - Madden, Pamela A F
AU - Martin, Nicholas G
AU - Montgomery, Grant W
AU - Christensen, Anne Francke
AU - Hansen, Thomas Folkmann
AU - Werge, Thomas
AU - Olesen, Jes
AU - International Headache Genetics Consortium
PY - 2016/8
Y1 - 2016/8
N2 - Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10(-8)) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.
AB - Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10(-8)) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.
KW - Journal Article
U2 - 10.1038/ng.3598
DO - 10.1038/ng.3598
M3 - Journal article
C2 - 27322543
VL - 48
SP - 856
EP - 866
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -
ID: 166689763