Mendelian randomisation study of the relationship between vitamin D and risk of glioma

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Mendelian randomisation study of the relationship between vitamin D and risk of glioma. / Takahashi, Hannah; Cornish, Alex J; Sud, Amit; Law, Philip J; Kinnersley, Ben; Ostrom, Quinn T; Labreche, Karim; Eckel-Passow, Jeanette E; Armstrong, Georgina N; Claus, Elizabeth B; Ll'yasova, Dora; Schildkraut, Joellen; Barnholtz-Sloan, Jill S; Olson, Sara H; Bernstein, Jonine L; Lai, Rose K; Schoemaker, Minouk J; Simon, Matthias; Hoffmann, Per; Nöthen, Markus M; Jöckel, Karl-Heinz; Chanock, Stephen; Rajaraman, Preetha; Johansen, Christoffer; Jenkins, Robert B; Melin, Beatrice S; Wrensch, Margaret R; Sanson, Marc; Bondy, Melissa L; Turnbull, Clare; Houlston, Richard S.

I: Scientific Reports, Bind 8, 2339, 2018.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Takahashi, H, Cornish, AJ, Sud, A, Law, PJ, Kinnersley, B, Ostrom, QT, Labreche, K, Eckel-Passow, JE, Armstrong, GN, Claus, EB, Ll'yasova, D, Schildkraut, J, Barnholtz-Sloan, JS, Olson, SH, Bernstein, JL, Lai, RK, Schoemaker, MJ, Simon, M, Hoffmann, P, Nöthen, MM, Jöckel, K-H, Chanock, S, Rajaraman, P, Johansen, C, Jenkins, RB, Melin, BS, Wrensch, MR, Sanson, M, Bondy, ML, Turnbull, C & Houlston, RS 2018, 'Mendelian randomisation study of the relationship between vitamin D and risk of glioma', Scientific Reports, bind 8, 2339. https://doi.org/10.1038/s41598-018-20844-w

APA

Takahashi, H., Cornish, A. J., Sud, A., Law, P. J., Kinnersley, B., Ostrom, Q. T., Labreche, K., Eckel-Passow, J. E., Armstrong, G. N., Claus, E. B., Ll'yasova, D., Schildkraut, J., Barnholtz-Sloan, J. S., Olson, S. H., Bernstein, J. L., Lai, R. K., Schoemaker, M. J., Simon, M., Hoffmann, P., ... Houlston, R. S. (2018). Mendelian randomisation study of the relationship between vitamin D and risk of glioma. Scientific Reports, 8, [2339]. https://doi.org/10.1038/s41598-018-20844-w

Vancouver

Takahashi H, Cornish AJ, Sud A, Law PJ, Kinnersley B, Ostrom QT o.a. Mendelian randomisation study of the relationship between vitamin D and risk of glioma. Scientific Reports. 2018;8. 2339. https://doi.org/10.1038/s41598-018-20844-w

Author

Takahashi, Hannah ; Cornish, Alex J ; Sud, Amit ; Law, Philip J ; Kinnersley, Ben ; Ostrom, Quinn T ; Labreche, Karim ; Eckel-Passow, Jeanette E ; Armstrong, Georgina N ; Claus, Elizabeth B ; Ll'yasova, Dora ; Schildkraut, Joellen ; Barnholtz-Sloan, Jill S ; Olson, Sara H ; Bernstein, Jonine L ; Lai, Rose K ; Schoemaker, Minouk J ; Simon, Matthias ; Hoffmann, Per ; Nöthen, Markus M ; Jöckel, Karl-Heinz ; Chanock, Stephen ; Rajaraman, Preetha ; Johansen, Christoffer ; Jenkins, Robert B ; Melin, Beatrice S ; Wrensch, Margaret R ; Sanson, Marc ; Bondy, Melissa L ; Turnbull, Clare ; Houlston, Richard S. / Mendelian randomisation study of the relationship between vitamin D and risk of glioma. I: Scientific Reports. 2018 ; Bind 8.

Bibtex

@article{d029d391f6724c3fb9747036c7666235,

title = "Mendelian randomisation study of the relationship between vitamin D and risk of glioma",

abstract = "To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH)D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH)D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90-1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98-1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43-0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37-1.04, P = 0.070). No statistically significant association was shown between 25(OH)D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH)D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH)D levels and risk of GBM.",

keywords = "Brain Neoplasms/blood, Genetic Predisposition to Disease, Genetic Variation, Glioma/blood, Humans, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Vitamin D/blood",

author = "Hannah Takahashi and Cornish, {Alex J} and Amit Sud and Law, {Philip J} and Ben Kinnersley and Ostrom, {Quinn T} and Karim Labreche and Eckel-Passow, {Jeanette E} and Armstrong, {Georgina N} and Claus, {Elizabeth B} and Dora Ll'yasova and Joellen Schildkraut and Barnholtz-Sloan, {Jill S} and Olson, {Sara H} and Bernstein, {Jonine L} and Lai, {Rose K} and Schoemaker, {Minouk J} and Matthias Simon and Per Hoffmann and N{\"o}then, {Markus M} and Karl-Heinz J{\"o}ckel and Stephen Chanock and Preetha Rajaraman and Christoffer Johansen and Jenkins, {Robert B} and Melin, {Beatrice S} and Wrensch, {Margaret R} and Marc Sanson and Bondy, {Melissa L} and Clare Turnbull and Houlston, {Richard S}",

year = "2018",

doi = "10.1038/s41598-018-20844-w",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Mendelian randomisation study of the relationship between vitamin D and risk of glioma

AU - Takahashi, Hannah

AU - Cornish, Alex J

AU - Sud, Amit

AU - Law, Philip J

AU - Kinnersley, Ben

AU - Ostrom, Quinn T

AU - Labreche, Karim

AU - Eckel-Passow, Jeanette E

AU - Armstrong, Georgina N

AU - Claus, Elizabeth B

AU - Ll'yasova, Dora

AU - Schildkraut, Joellen

AU - Barnholtz-Sloan, Jill S

AU - Olson, Sara H

AU - Bernstein, Jonine L

AU - Lai, Rose K

AU - Schoemaker, Minouk J

AU - Simon, Matthias

AU - Hoffmann, Per

AU - Nöthen, Markus M

AU - Jöckel, Karl-Heinz

AU - Chanock, Stephen

AU - Rajaraman, Preetha

AU - Johansen, Christoffer

AU - Jenkins, Robert B

AU - Melin, Beatrice S

AU - Wrensch, Margaret R

AU - Sanson, Marc

AU - Bondy, Melissa L

AU - Turnbull, Clare

AU - Houlston, Richard S

PY - 2018

Y1 - 2018

N2 - To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH)D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH)D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90-1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98-1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43-0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37-1.04, P = 0.070). No statistically significant association was shown between 25(OH)D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH)D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH)D levels and risk of GBM.

AB - To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH)D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH)D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90-1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98-1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43-0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37-1.04, P = 0.070). No statistically significant association was shown between 25(OH)D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH)D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH)D levels and risk of GBM.

KW - Brain Neoplasms/blood

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Glioma/blood

KW - Humans

KW - Mendelian Randomization Analysis

KW - Polymorphism, Single Nucleotide

KW - Vitamin D/blood

UR - https://www.nature.com/articles/s41598-019-43787-2

U2 - 10.1038/s41598-018-20844-w

DO - 10.1038/s41598-018-20844-w

M3 - Journal article

C2 - 29402980

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 2339

ER -

ID: 218086631