Melatonin Secretion Pattern in Critically Ill Patients: A Pilot Descriptive Study
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Melatonin Secretion Pattern in Critically Ill Patients : A Pilot Descriptive Study. / Boyko, Yuliya; Holst, René; Jennum, Poul; Oerding, Helle; Nikolic, Miki; Toft, Palle.
I: Critical Care Research and Practice, Bind 2017, 7010854, 2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Melatonin Secretion Pattern in Critically Ill Patients
T2 - A Pilot Descriptive Study
AU - Boyko, Yuliya
AU - Holst, René
AU - Jennum, Poul
AU - Oerding, Helle
AU - Nikolic, Miki
AU - Toft, Palle
PY - 2017
Y1 - 2017
N2 - Critically ill patients have abnormal circadian and sleep homeostasis. This may be associated with higher morbidity and mortality. The aims of this pilot study were (1) to describe melatonin secretion in conscious critically ill mechanically ventilated patients and (2) to describe whether melatonin secretion and sleep patterns differed in these patients with and without remifentanil infusion. Eight patients were included. Blood-melatonin was taken every 4th hour, and polysomnography was carried out continually during a 48-hour period. American Academy of Sleep Medicine criteria were used for sleep scoring if sleep patterns were identified; otherwise, Watson's classification was applied. As remifentanil was periodically administered during the study, its effect on melatonin and sleep was assessed. Melatonin secretion in these patients followed a phase-delayed diurnal curve. We did not observe any effect of remifentanil on melatonin secretion. We found that the risk of atypical sleep compared to normal sleep was significantly lower (p<0.001) under remifentanil infusion. Rapid Eye Movement (REM) sleep was only observed during the nonsedation period. We found preserved diurnal pattern of melatonin secretion in these patients. Remifentanil did not affect melatonin secretion but was associated with lower risk of atypical sleep pattern. REM sleep was only registered during the period of nonsedation.
AB - Critically ill patients have abnormal circadian and sleep homeostasis. This may be associated with higher morbidity and mortality. The aims of this pilot study were (1) to describe melatonin secretion in conscious critically ill mechanically ventilated patients and (2) to describe whether melatonin secretion and sleep patterns differed in these patients with and without remifentanil infusion. Eight patients were included. Blood-melatonin was taken every 4th hour, and polysomnography was carried out continually during a 48-hour period. American Academy of Sleep Medicine criteria were used for sleep scoring if sleep patterns were identified; otherwise, Watson's classification was applied. As remifentanil was periodically administered during the study, its effect on melatonin and sleep was assessed. Melatonin secretion in these patients followed a phase-delayed diurnal curve. We did not observe any effect of remifentanil on melatonin secretion. We found that the risk of atypical sleep compared to normal sleep was significantly lower (p<0.001) under remifentanil infusion. Rapid Eye Movement (REM) sleep was only observed during the nonsedation period. We found preserved diurnal pattern of melatonin secretion in these patients. Remifentanil did not affect melatonin secretion but was associated with lower risk of atypical sleep pattern. REM sleep was only registered during the period of nonsedation.
U2 - 10.1155/2017/7010854
DO - 10.1155/2017/7010854
M3 - Journal article
C2 - 28584667
AN - SCOPUS:85019586007
VL - 2017
JO - Critical Care Research and Practice
JF - Critical Care Research and Practice
SN - 2090-1305
M1 - 7010854
ER -
ID: 196441297