Mechanisms of transcription-coupled DNA repair
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Mechanisms of transcription-coupled DNA repair. / Svejstrup, Jesper Q.
I: Nature Reviews Molecular Cell Biology, Bind 3, Nr. 1, 01.2002, s. 21-29.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mechanisms of transcription-coupled DNA repair
AU - Svejstrup, Jesper Q.
N1 - Funding Information: Work relevant to this review was supported by an in-house grant from the Imperial Cancer Research Fund. T. Lindahl and B. Winkler are thanked for their comments and suggestions.
PY - 2002/1
Y1 - 2002/1
N2 - Several types of helix-distorting DNA lesions block the passage of elongating RNA polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired considerably faster than non-obstructive lesions in the non-transcribed strand or in the genome overall. In this review, our knowledge of eukaryotic transcription-coupled repair (TCR) will be considered from the point of view of transcription, and current models for the mechanism of TCR will be discussed.
AB - Several types of helix-distorting DNA lesions block the passage of elongating RNA polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired considerably faster than non-obstructive lesions in the non-transcribed strand or in the genome overall. In this review, our knowledge of eukaryotic transcription-coupled repair (TCR) will be considered from the point of view of transcription, and current models for the mechanism of TCR will be discussed.
UR - http://www.scopus.com/inward/record.url?scp=0036363646&partnerID=8YFLogxK
U2 - 10.1038/nrm703
DO - 10.1038/nrm703
M3 - Review
C2 - 11823795
AN - SCOPUS:0036363646
VL - 3
SP - 21
EP - 29
JO - Nature Reviews. Molecular Cell Biology
JF - Nature Reviews. Molecular Cell Biology
SN - 1471-0072
IS - 1
ER -
ID: 331042747