Measuring and evaluating interferon beta-induced antibodies in patients with multiple sclerosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Measuring and evaluating interferon beta-induced antibodies in patients with multiple sclerosis. / Ross, C; Clemmesen, K M; Sørensen, P S; Koch-Henriksen, Nils; Bendtzen, K.
I: Multiple Sclerosis, Bind 12, Nr. 1, 01.02.2006, s. 39-46.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Measuring and evaluating interferon beta-induced antibodies in patients with multiple sclerosis
AU - Ross, C
AU - Clemmesen, K M
AU - Sørensen, P S
AU - Koch-Henriksen, Nils
AU - Bendtzen, K
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Administration of interferons (IFNs) may induce antibodies that interfere with therapeutic efficacy. We have optimized and validated methods for large-scale economic screening. Sera from patients with relapsing-remitting multiple sclerosis (MS) were investigated for binding antibody (BAb) by protein-G affinity-chromatography radioimmunoassay and a commercially available enzyme immunoassay (EIA). Neutralizing antibody (NAb) was investigated by cytopathic effect assays (CEA) using both fixed amount and serially diluted sera. BAb correlated with log10-transformed titres obtained by EIA (r=0.70, P
AB - Administration of interferons (IFNs) may induce antibodies that interfere with therapeutic efficacy. We have optimized and validated methods for large-scale economic screening. Sera from patients with relapsing-remitting multiple sclerosis (MS) were investigated for binding antibody (BAb) by protein-G affinity-chromatography radioimmunoassay and a commercially available enzyme immunoassay (EIA). Neutralizing antibody (NAb) was investigated by cytopathic effect assays (CEA) using both fixed amount and serially diluted sera. BAb correlated with log10-transformed titres obtained by EIA (r=0.70, P
M3 - Journal article
VL - 12
SP - 39
EP - 46
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 1
ER -
ID: 34092834