Measurements of glucose phosphorylation with FDG and PET are not reduced by dephosphorylation of FDG-6-phosphate.
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Measurements of glucose phosphorylation with FDG and PET are not reduced by dephosphorylation of FDG-6-phosphate. / Kuwabara, H; Gjedde, A.
I: Journal of Nuclear Medicine, Bind 32, Nr. 4, 1991, s. 692-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Measurements of glucose phosphorylation with FDG and PET are not reduced by dephosphorylation of FDG-6-phosphate.
AU - Kuwabara, H
AU - Gjedde, A
PY - 1991
Y1 - 1991
N2 - To improve the measurements of glucose metabolism in the human brain, we imposed biologic constraints on the deoxyglucose model with and without dephosphorylation of FDG-6-phosphate (the k4*- and k3*-models). The constraints included constant transport and phosphorylation ratios (tau and phi) and a common partition volume (K1/k2) for tracer [18F]FDG and glucose. In the presence of significant dephosphorylation, the k3*-model yielded time-dependent estimates of the phosphorylation coefficient (k3*), while the K4*-model yielded time-independent estimates. However, the two models yielded practically identical measurements of regional cerebral glucose metabolism in PET studies of six normal volunteers when the phosphorylation affinity ratio (the k3*/k3 ratio of FDG and glucose) and tracer circulation time were 0.30 and 20 min for the k3*-model and 0.33 and 45 min for the k4*-model.
AB - To improve the measurements of glucose metabolism in the human brain, we imposed biologic constraints on the deoxyglucose model with and without dephosphorylation of FDG-6-phosphate (the k4*- and k3*-models). The constraints included constant transport and phosphorylation ratios (tau and phi) and a common partition volume (K1/k2) for tracer [18F]FDG and glucose. In the presence of significant dephosphorylation, the k3*-model yielded time-dependent estimates of the phosphorylation coefficient (k3*), while the K4*-model yielded time-independent estimates. However, the two models yielded practically identical measurements of regional cerebral glucose metabolism in PET studies of six normal volunteers when the phosphorylation affinity ratio (the k3*/k3 ratio of FDG and glucose) and tracer circulation time were 0.30 and 20 min for the k3*-model and 0.33 and 45 min for the k4*-model.
M3 - Journal article
C2 - 2013809
VL - 32
SP - 692
EP - 698
JO - The Journal of Nuclear Medicine
JF - The Journal of Nuclear Medicine
SN - 0161-5505
IS - 4
ER -
ID: 14946776