Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients
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Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. / Christiansen, Ole B; Kolte, Astrid M; Dahl, Mette; Larsen, Elisabeth C; Steffensen, Rudi; Nielsen, Henriette S; Hviid, Thomas V.
I: Human Immunology, Bind 73, Nr. 7, 07.2012, s. 699-705.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients
AU - Christiansen, Ole B
AU - Kolte, Astrid M
AU - Dahl, Mette
AU - Larsen, Elisabeth C
AU - Steffensen, Rudi
AU - Nielsen, Henriette S
AU - Hviid, Thomas V
N1 - Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
PY - 2012/7
Y1 - 2012/7
N2 - Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p
AB - Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p
KW - Abortion, Habitual
KW - Alleles
KW - DNA Mutational Analysis
KW - Female
KW - Genetic Predisposition to Disease
KW - H-Y Antigen
KW - HLA-G Antigens
KW - Histocompatibility Antigens Class II
KW - Homozygote
KW - Humans
KW - Immunity
KW - Infant, Low Birth Weight
KW - Infant, Newborn
KW - Male
KW - Mutagenesis, Insertional
KW - Polymorphism, Genetic
KW - Protein Binding
U2 - 10.1016/j.humimm.2012.04.014
DO - 10.1016/j.humimm.2012.04.014
M3 - Journal article
C2 - 22537754
VL - 73
SP - 699
EP - 705
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 7
ER -
ID: 47923510