Maternal concentrations of phthalates and Attention-Deficit Hyperactivity Disorder (ADHD-) related symptoms in children aged 2 to 4 years from Odense child cohort
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 892 KB, PDF-dokument
Phthalates are endocrine disrupting chemicals used in everyday consumer products. Several epidemiological studies have examined the association between prenatal phthalate concentration and Attention-Deficit Hyperactivity Disorder (ADHD) in offspring, but the findings have been inconclusive.
Objectives
To investigate the association between maternal urinary concentrations of phthalate metabolites during pregnancy and ADHD related symptoms in children at 2 to 4 years in a large prospective cohort.
Methods
In the Odense Child Cohort from Denmark were women recruited in early pregnancy from 2010 to 2012. Phthalate concentrations were measured in urine samples collected in 3rd trimester and separated into low and high weight phthalates. Parents filled in the Child Behavior Checklist for ages 1.5 to 5 years (CBCL/1½-5), including a 6-item ADHD symptom scale at children aged 2 to 4 years. Data were analysed by use of adjusted negative binomial regression.
Results
A total of 658 mother–child pairs were included. Urinary phthalate metabolite concentrations were generally low compared to previous cohorts. A doubling in maternal concentration of the low-weighted phthalate metabolite MCPP was significantly associated with lower ADHD symptoms score in children (IRR: 0.95 (95 % CI 0.91–0.98)), strongest in girls (IRR: 0.92 (0.87–0.98)). Sex differences were observed. High maternal phthalate metabolite concentrations were associated with lower ADHD symptom score in girls, significant trends across tertile of MCPP and MnBP (p = 0.018, p = 0.038, respectively). In boys, maternal concentrations of high-molecular-weight phthalates (MBzP, ∑DiNP and ∑DEHP) were associated with an almost significantly higher ADHD symptom score (IRR for a doubling in concentration: 1.04 (95 % CI: 0.99–1.10), IRR: 1.05 (95 % CI: 0.97–1.13), IRR: 1.04 (95 % CI: 0.99–1.10), respectively).
Conclusion
Maternal concentration of the low-weighted phthalate metabolite MCPP was significantly associated with a lower ADHD symptom score in children, strongest in girls. Maternal concentrations of high-molecular-weight phthalates were associated with non-significant increase in ADHD symptom score in boys.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 108244 |
| Tidsskrift | Environment International |
| Vol/bind | 180 |
| Antal sider | 10 |
| ISSN | 0160-4120 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The participants in the Odense Child Cohort. The technicians at Hans Christian Andersen's Children's Hospital are acknowledged for their careful examination of the children. The lab technicians at Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark and Department of Growth and Reproduction, Rigshospitalet are acknowledged for their thorough work in analyzing the urine samples. This work was supported by Odense University Hospital, Denmark, the Region of Southern Denmark, The National Board of Social Services, The Municipality of Odense, Denmark, The University of Southern Denmark, the Mental Health Service of the Region of Southern Denmark, Odense Patient data Exploratory Network (OPEN), Denmark, The Danish Center for Hormone Disrupting Chemicals (MST-611-00012), The Danish Research Council (4004-00352B_FSS), Novo Nordisk Foundation, Denmark (grant no. NNF19OC0058266 and NNF17OC0029404), HBM4EU, Sygeforsikring Danmark (journalnr. 2021-0173). The Collaborative foundation between Odense University Hospital and Rigshospitalet, Helsefonden, the Danish Mental Health Fund. The LS-MS/MS equipment was financially supported by the Velux Foundation.
Funding Information:
The participants in the Odense Child Cohort. The technicians at Hans Christian Andersen’s Children’s Hospital are acknowledged for their careful examination of the children. The lab technicians at Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark and Department of Growth and Reproduction, Rigshospitalet are acknowledged for their thorough work in analyzing the urine samples. This work was supported by Odense University Hospital, Denmark, the Region of Southern Denmark, The National Board of Social Services, The Municipality of Odense, Denmark, The University of Southern Denmark, the Mental Health Service of the Region of Southern Denmark, Odense Patient data Exploratory Network (OPEN), Denmark, The Danish Center for Hormone Disrupting Chemicals (MST-611-00012), The Danish Research Council (4004-00352B_FSS), Novo Nordisk Foundation, Denmark (grant no. NNF19OC0058266 and NNF17OC0029404), HBM4EU, Sygeforsikring Danmark (journalnr. 2021-0173). The Collaborative foundation between Odense University Hospital and Rigshospitalet, Helsefonden, the Danish Mental Health Fund. The LS-MS/MS equipment was financially supported by the Velux Foundation.
Publisher Copyright:
© 2023
ID: 375795612