Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects. / Bradley, David; Magkos, Faidon; Eagon, J Christopher; Varela, J Esteban; Gastaldelli, Amalia; Okunade, Adewole L; Patterson, Bruce W; Klein, Samuel.
I: Obesity, Bind 22, Nr. 9, 2014, s. 2026-2031.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects
AU - Bradley, David
AU - Magkos, Faidon
AU - Eagon, J Christopher
AU - Varela, J Esteban
AU - Gastaldelli, Amalia
AU - Okunade, Adewole L
AU - Patterson, Bruce W
AU - Klein, Samuel
N1 - © 2014 The Obesity Society.
PY - 2014
Y1 - 2014
N2 - Objective: The effects of marked weight loss, induced by Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgeries, on insulin sensitivity, β-cell function and the metabolic response to a mixed meal were evaluated.Methods: Fourteen nondiabetic insulin-resistant patients who were scheduled to undergo SG (n = 7) or RYGB (n = 7) procedures completed a hyperinsulinemic-euglycemic clamp procedure and a mixed-meal tolerance test before surgery and after losing ∼20% of their initial body weight.Results: Insulin sensitivity (insulin-stimulated glucose disposal during a clamp procedure), oral glucose tolerance (postprandial plasma glucose area under the curve), and β-cell function (insulin secretion in relationship to insulin sensitivity) improved after weight loss, and were not different between surgical groups. The metabolic response to meal ingestion was similar after RYGB or SG, manifested by rapid delivery of ingested glucose into the systemic circulation and a large early postprandial increase in plasma glucose, insulin, and C-peptide concentrations in both groups.Conclusions: When matched on weight loss, RYGB and SG surgeries result in similar improvements in the two major factors involved in regulating plasma glucose homeostasis, insulin sensitivity and β-cell function in obese people without diabetes.
AB - Objective: The effects of marked weight loss, induced by Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgeries, on insulin sensitivity, β-cell function and the metabolic response to a mixed meal were evaluated.Methods: Fourteen nondiabetic insulin-resistant patients who were scheduled to undergo SG (n = 7) or RYGB (n = 7) procedures completed a hyperinsulinemic-euglycemic clamp procedure and a mixed-meal tolerance test before surgery and after losing ∼20% of their initial body weight.Results: Insulin sensitivity (insulin-stimulated glucose disposal during a clamp procedure), oral glucose tolerance (postprandial plasma glucose area under the curve), and β-cell function (insulin secretion in relationship to insulin sensitivity) improved after weight loss, and were not different between surgical groups. The metabolic response to meal ingestion was similar after RYGB or SG, manifested by rapid delivery of ingested glucose into the systemic circulation and a large early postprandial increase in plasma glucose, insulin, and C-peptide concentrations in both groups.Conclusions: When matched on weight loss, RYGB and SG surgeries result in similar improvements in the two major factors involved in regulating plasma glucose homeostasis, insulin sensitivity and β-cell function in obese people without diabetes.
KW - Adult
KW - Blood Glucose/metabolism
KW - C-Peptide/blood
KW - Case-Control Studies
KW - Female
KW - Gastrectomy/methods
KW - Gastric Bypass/methods
KW - Glucose Clamp Technique
KW - Glucose Tolerance Test
KW - Humans
KW - Insulin/blood
KW - Insulin Resistance
KW - Insulin-Secreting Cells/physiology
KW - Male
KW - Middle Aged
KW - Obesity, Morbid/metabolism
KW - Postprandial Period
KW - Weight Loss/physiology
U2 - 10.1002/oby.20803
DO - 10.1002/oby.20803
M3 - Journal article
C2 - 24891156
VL - 22
SP - 2026
EP - 2031
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 9
ER -
ID: 289965509