Marked Increase in Incident Gynecomastia: A 20-Year National Registry Study, 1998 to 2017
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Marked Increase in Incident Gynecomastia : A 20-Year National Registry Study, 1998 to 2017. / Koch, Trine; Bräuner, Elvira V; Busch, Alexander S; Hickey, Martha; Juul, Anders.
I: Journal of Clinical Endocrinology and Metabolism, Bind 105, Nr. 10, 2020, s. 3134–3140.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Marked Increase in Incident Gynecomastia
T2 - A 20-Year National Registry Study, 1998 to 2017
AU - Koch, Trine
AU - Bräuner, Elvira V
AU - Busch, Alexander S
AU - Hickey, Martha
AU - Juul, Anders
N1 - © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2020
Y1 - 2020
N2 - CONTEXT: Gynecomastia, the proliferation of mammary glandular tissue in the male, is a frequent but little-studied condition. Available prevalence data are based on selected patient populations or autopsy cases with their inherent bias.OBJECTIVE: The objective of this work is to evaluate the age-related incidence and secular trends in gynecomastia in the general population.DESIGN: An observational, 20-year national registry study was conducted.SETTING: This population-based study used nationwide registry data.PARTICIPANTS: Participants included all Danish males (age 0-80 years) with a first-time diagnosis of gynecomastia.MAIN OUTCOME MEASURES: All Danish males (age 0-80 years) were followed up for incident diagnosis of gynecomastia in the Danish National Patient Registry from 1998 to 2017 using the International Codes of Diseases, 10th revision, and the Danish Health Care Classification System. Age-specific incidence rates were estimated. The hypothesis tested in this study was formulated prior to data collection.RESULTS: Overall, a total 17 601 males (age 0-80 years) were registered with an incident diagnosis of gynecomastia within the 20-year study period, corresponding to 880 new cases per year and an average 20-year incidence of 3.4 per 10 000 men (age 0-80 years). The average annual incidence was 6.5/10 000 in postpubertal males age 16 to 20 years and 4.6/10 000 in males age 61 to 80 years, with a respective 5- and 11-fold overall increase in these 2 age groups over the 20-year period.CONCLUSIONS: The incidence of gynecomastia has dramatically increased over the last 20 years, implying that the endogenous or exogenous sex-steroid environment has changed, which is associated with other adverse health consequences in men such as an increased risk of prostate cancer, metabolic syndrome, type 2 diabetes, or cardiovascular disorders.
AB - CONTEXT: Gynecomastia, the proliferation of mammary glandular tissue in the male, is a frequent but little-studied condition. Available prevalence data are based on selected patient populations or autopsy cases with their inherent bias.OBJECTIVE: The objective of this work is to evaluate the age-related incidence and secular trends in gynecomastia in the general population.DESIGN: An observational, 20-year national registry study was conducted.SETTING: This population-based study used nationwide registry data.PARTICIPANTS: Participants included all Danish males (age 0-80 years) with a first-time diagnosis of gynecomastia.MAIN OUTCOME MEASURES: All Danish males (age 0-80 years) were followed up for incident diagnosis of gynecomastia in the Danish National Patient Registry from 1998 to 2017 using the International Codes of Diseases, 10th revision, and the Danish Health Care Classification System. Age-specific incidence rates were estimated. The hypothesis tested in this study was formulated prior to data collection.RESULTS: Overall, a total 17 601 males (age 0-80 years) were registered with an incident diagnosis of gynecomastia within the 20-year study period, corresponding to 880 new cases per year and an average 20-year incidence of 3.4 per 10 000 men (age 0-80 years). The average annual incidence was 6.5/10 000 in postpubertal males age 16 to 20 years and 4.6/10 000 in males age 61 to 80 years, with a respective 5- and 11-fold overall increase in these 2 age groups over the 20-year period.CONCLUSIONS: The incidence of gynecomastia has dramatically increased over the last 20 years, implying that the endogenous or exogenous sex-steroid environment has changed, which is associated with other adverse health consequences in men such as an increased risk of prostate cancer, metabolic syndrome, type 2 diabetes, or cardiovascular disorders.
KW - Adolescent
KW - Adult
KW - Age Distribution
KW - Aged
KW - Aged, 80 and over
KW - Child
KW - Child, Preschool
KW - Denmark/epidemiology
KW - Female
KW - Follow-Up Studies
KW - Gynecomastia/epidemiology
KW - Humans
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Aged
KW - Registries/statistics & numerical data
KW - Risk Factors
KW - Young Adult
U2 - 10.1210/clinem/dgaa440
DO - 10.1210/clinem/dgaa440
M3 - Journal article
C2 - 32754750
VL - 105
SP - 3134
EP - 3140
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 10
ER -
ID: 259056777