Mannose-binding lectin genetics: from A to Z

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Mannose-binding lectin genetics: from A to Z. / Garred, Peter.

I: Biochemical Society Transactions, Bind 36, Nr. Pt 6, 2008, s. 1461-1466.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Garred, P 2008, 'Mannose-binding lectin genetics: from A to Z', Biochemical Society Transactions, bind 36, nr. Pt 6, s. 1461-1466. https://doi.org/10.1042/BST0361461

APA

Garred, P. (2008). Mannose-binding lectin genetics: from A to Z. Biochemical Society Transactions, 36(Pt 6), 1461-1466. https://doi.org/10.1042/BST0361461

Vancouver

Garred P. Mannose-binding lectin genetics: from A to Z. Biochemical Society Transactions. 2008;36(Pt 6):1461-1466. https://doi.org/10.1042/BST0361461

Author

Garred, Peter. / Mannose-binding lectin genetics: from A to Z. I: Biochemical Society Transactions. 2008 ; Bind 36, Nr. Pt 6. s. 1461-1466.

Bibtex

@article{9db465d0f68d11ddbf70000ea68e967b,
title = "Mannose-binding lectin genetics: from A to Z",
abstract = "MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. Common variant alleles situated both in promoter and structural regions of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variations in MBL serum concentrations influence the susceptibility to and the course of different types of infectious, autoimmune, neoplastic, metabolic and cardiovascular diseases, but this is still a subject under discussion. The fact that these genetic variations are very frequent, indicates a dual role of MBL. This overview summarizes the current molecular understanding of human MBL2 genetics.",
author = "Peter Garred",
note = "Keywords: Alleles; Gene Frequency; Genetics, Population; Humans; Mannose-Binding Lectin; Polymorphism, Genetic",
year = "2008",
doi = "10.1042/BST0361461",
language = "English",
volume = "36",
pages = "1461--1466",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "Pt 6",

}

RIS

TY - JOUR

T1 - Mannose-binding lectin genetics: from A to Z

AU - Garred, Peter

N1 - Keywords: Alleles; Gene Frequency; Genetics, Population; Humans; Mannose-Binding Lectin; Polymorphism, Genetic

PY - 2008

Y1 - 2008

N2 - MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. Common variant alleles situated both in promoter and structural regions of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variations in MBL serum concentrations influence the susceptibility to and the course of different types of infectious, autoimmune, neoplastic, metabolic and cardiovascular diseases, but this is still a subject under discussion. The fact that these genetic variations are very frequent, indicates a dual role of MBL. This overview summarizes the current molecular understanding of human MBL2 genetics.

AB - MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. Common variant alleles situated both in promoter and structural regions of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variations in MBL serum concentrations influence the susceptibility to and the course of different types of infectious, autoimmune, neoplastic, metabolic and cardiovascular diseases, but this is still a subject under discussion. The fact that these genetic variations are very frequent, indicates a dual role of MBL. This overview summarizes the current molecular understanding of human MBL2 genetics.

U2 - 10.1042/BST0361461

DO - 10.1042/BST0361461

M3 - Journal article

C2 - 19021576

VL - 36

SP - 1461

EP - 1466

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - Pt 6

ER -

ID: 10209142