Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study
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Mannose-binding lectin and risk of infections in type 2 diabetes : A Danish cohort study. / Gedebjerg, Anne; Thomsen, Reimar Wernich; Kjaergaard, Alisa Devedzic; Steffensen, Rudi; Nielsen, Jens Steen; Rungby, Jørgen; Friborg, Søren Gunnar; Brandslund, Ivan; Thiel, Steffen; Beck-Nielsen, Henning; Sørensen, Henrik Toft; Hansen, Troels Krarup; Bjerre, Mette.
I: Journal of Diabetes and its Complications, Bind 35, Nr. 5, 107873, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mannose-binding lectin and risk of infections in type 2 diabetes
T2 - A Danish cohort study
AU - Gedebjerg, Anne
AU - Thomsen, Reimar Wernich
AU - Kjaergaard, Alisa Devedzic
AU - Steffensen, Rudi
AU - Nielsen, Jens Steen
AU - Rungby, Jørgen
AU - Friborg, Søren Gunnar
AU - Brandslund, Ivan
AU - Thiel, Steffen
AU - Beck-Nielsen, Henning
AU - Sørensen, Henrik Toft
AU - Hansen, Troels Krarup
AU - Bjerre, Mette
N1 - Publisher Copyright: © 2021 Elsevier Inc.
PY - 2021
Y1 - 2021
N2 - Aims: In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes. Methods: Serum MBL (n = 7305) and MBL genotype (n = 3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8 years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses. Results: 1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100 μg/L) versus intermediate (101–1000 μg/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96–1.33) for any hospital-treated infections and 1.19(1.01–1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04–4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04–2.34] and antibacterial prescriptions 1.20[1.05–1.36]). Conclusions: Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.
AB - Aims: In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes. Methods: Serum MBL (n = 7305) and MBL genotype (n = 3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8 years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses. Results: 1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100 μg/L) versus intermediate (101–1000 μg/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96–1.33) for any hospital-treated infections and 1.19(1.01–1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04–4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04–2.34] and antibacterial prescriptions 1.20[1.05–1.36]). Conclusions: Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.
KW - Association
KW - Cohort study
KW - Epidemiology
KW - Infection
KW - Mannose-binding lectin
KW - Type 2 diabetes
U2 - 10.1016/j.jdiacomp.2021.107873
DO - 10.1016/j.jdiacomp.2021.107873
M3 - Journal article
C2 - 33627253
AN - SCOPUS:85101138809
VL - 35
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 5
M1 - 107873
ER -
ID: 301140040