Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice
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Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. / Giordano, Antonio; Perugini, Jessica; Kristensen, David Møbjerg; Sartini, Loris; Frontini, Andrea; Kajimura, Shingo; Kristiansen, Karsten; Cinti, Saverio.
I: Journal of Cellular Physiology, Bind 232, Nr. 11, 2017, s. 2923-2928.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice
AU - Giordano, Antonio
AU - Perugini, Jessica
AU - Kristensen, David Møbjerg
AU - Sartini, Loris
AU - Frontini, Andrea
AU - Kajimura, Shingo
AU - Kristiansen, Karsten
AU - Cinti, Saverio
PY - 2017
Y1 - 2017
N2 - During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary glandtransdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate bytransmission electron microscopy that in the post-lactating mammary gland interscapularmultilocular adipocytes found close to the mammary alveoli contain milk protein granules. Useof the Cre-loxP recombination system allowed showing that the involuting mammary gland ofwhey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene duringpregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapularmultilocular adipocytes. These data suggest that during mammary gland involution some milk-secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brownadipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity
AB - During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary glandtransdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate bytransmission electron microscopy that in the post-lactating mammary gland interscapularmultilocular adipocytes found close to the mammary alveoli contain milk protein granules. Useof the Cre-loxP recombination system allowed showing that the involuting mammary gland ofwhey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene duringpregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapularmultilocular adipocytes. These data suggest that during mammary gland involution some milk-secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brownadipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity
KW - adipose organ
KW - Cre-loxP recombination system
KW - electron microscopy
KW - mammary gland
KW - pregnancy
U2 - 10.1002/jcp.25858
DO - 10.1002/jcp.25858
M3 - Journal article
C2 - 28191637
VL - 232
SP - 2923
EP - 2928
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 11
ER -
ID: 183637824