Lysosomal cell death at a glance
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Lysosomal cell death at a glance. / Aits, Sonja; Jaattela, Marja.
I: Journal of Cell Science, Bind 126, Nr. Pt 9, 01.05.2013, s. 1905-12.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Lysosomal cell death at a glance
AU - Aits, Sonja
AU - Jaattela, Marja
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.
AB - Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.
U2 - 10.1242/jcs.091181
DO - 10.1242/jcs.091181
M3 - Journal article
C2 - 23720375
VL - 126
SP - 1905
EP - 1912
JO - Journal of Cell Science
JF - Journal of Cell Science
SN - 0021-9533
IS - Pt 9
ER -
ID: 47714518