TY - JOUR

T1 - Lymphomas of the salivary glands

T2 - a systematic review

AU - Al-Khafaf, Ahmed Ehsan

AU - Al-Shahrestani, Fahd

AU - Baysal, Yusuf

AU - Rahbek Gjerdrum, Lise Mette

AU - Heegaard, Steffen

AU - Pedersen, Lars Møller

AU - Homøe, Preben

N1 - Publisher Copyright: © 2023 Acta Oto-Laryngologica AB (Ltd).

PY - 2023

Y1 - 2023

N2 - Background: Lymphomas constitute 2% of all salivary gland tumors and are the second most common group of malignancies in the head and neck region. Objectives: In this systematic review, the demographics and characteristics of salivary gland lymphomas are presented. Methods: All types of studies that involve data of salivary gland lymphomas between 1990 and 2020 were identified and screened. Results: A total of 169 articles with 1640 patients were identified. The median age of the patients was 59 years with a range between 10 and 87 years. The anatomic locations of salivary gland lymphomas were distributed with 88% in the parotid glands, 9% in the submandibular glands, 1% in the minor salivary glands, and 0.3% in the sublingual glands. The overall survival at 12 months is high and in line with the outcome of indolent lymphomas in general. The predominant indolent subtypes were extranodal marginal zone lymphomas and follicular lymphomas, whereas the more aggressive subtypes were mainly diffuse large B-cell lymphomas, mantle cell lymphomas, and T-cell lymphomas. Conclusion: In conclusion, lymphomas occur in all salivary glands and mainly in elderly female patients. Sjögren’s syndrome is frequently associated. Depending on the anatomical location, the lymphoma subtypes vary in aggressiveness, stage, and prognosis.

AB - Background: Lymphomas constitute 2% of all salivary gland tumors and are the second most common group of malignancies in the head and neck region. Objectives: In this systematic review, the demographics and characteristics of salivary gland lymphomas are presented. Methods: All types of studies that involve data of salivary gland lymphomas between 1990 and 2020 were identified and screened. Results: A total of 169 articles with 1640 patients were identified. The median age of the patients was 59 years with a range between 10 and 87 years. The anatomic locations of salivary gland lymphomas were distributed with 88% in the parotid glands, 9% in the submandibular glands, 1% in the minor salivary glands, and 0.3% in the sublingual glands. The overall survival at 12 months is high and in line with the outcome of indolent lymphomas in general. The predominant indolent subtypes were extranodal marginal zone lymphomas and follicular lymphomas, whereas the more aggressive subtypes were mainly diffuse large B-cell lymphomas, mantle cell lymphomas, and T-cell lymphomas. Conclusion: In conclusion, lymphomas occur in all salivary glands and mainly in elderly female patients. Sjögren’s syndrome is frequently associated. Depending on the anatomical location, the lymphoma subtypes vary in aggressiveness, stage, and prognosis.

KW - Ann Arbor staging

KW - autoimmune disease

KW - cancer

KW - head and neck

KW - Lymphoma

KW - salivary glands

KW - Sjögren’s syndrome

U2 - 10.1080/00016489.2023.2226689

DO - 10.1080/00016489.2023.2226689

M3 - Review

C2 - 37572309

AN - SCOPUS:85167916726

VL - 143

SP - 610

EP - 616

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 7

ER -