Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial
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Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial. / Holt, Rune; Yahyavi, Sam Kafai; Wall-Gremstrup, Gustav; Jorsal, Mads Joon; Toft, Frederikke Bay; Jørgensen, Niels; Juul, Anders; Jensen, Martin Blomberg.
I: Fertility and Sterility, Bind 122, Nr. 2, 2024, s. 278-287.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial
AU - Holt, Rune
AU - Yahyavi, Sam Kafai
AU - Wall-Gremstrup, Gustav
AU - Jorsal, Mads Joon
AU - Toft, Frederikke Bay
AU - Jørgensen, Niels
AU - Juul, Anders
AU - Jensen, Martin Blomberg
N1 - Publisher Copyright: © 2024 American Society for Reproductive Medicine
PY - 2024
Y1 - 2024
N2 - Objective: To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. Design: Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial. Setting: Not applicable. Patients: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration. Intervention: Not applicable. Main Outcome Measures: Serum AMH concentration and semen quality. Results: All men were stratified according to serum AMH concentrations in quartiles (Q1–Q4). Men in the lowest quartile had a lower sperm concentration (1 × 106/mL) (Q1: 8.0 vs. Q2: 10.4 vs. Q3: 11.0 vs. Q4: 13.0), total sperm count (1 × 106) (Q1: 29.1 vs. Q2: 38.2 vs. Q3: 44.4 vs. Q4: 55.7), sperm motility (%) (Q1: 41 vs. Q2: 57 vs. Q3: 50 vs. Q4: 53), and progressive sperm motility (%) (Q1: 31 vs. Q2: 44 vs. Q3: 35 vs. Q4: 40) compared with the other quartiles. Moreover, men with a sperm concentration <2 million/mL had a lower serum AMH concentration compared with men having 2–16 × 106 /mL and >16 × 106/mL (31 pmol/L vs. 38 pmol/L vs. 43 pmol/L, respectively). In accordance, men with sperm motility <20% had a lower serum AMH concentration compared with men with sperm motility 20%–42%, and >42% (31 pmol/L vs. 43 pmol/L. vs. 39 pmol/L, respectively). Conclusion: This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility. Clinical Trial Registration Number: NCT05212337
AB - Objective: To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. Design: Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial. Setting: Not applicable. Patients: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration. Intervention: Not applicable. Main Outcome Measures: Serum AMH concentration and semen quality. Results: All men were stratified according to serum AMH concentrations in quartiles (Q1–Q4). Men in the lowest quartile had a lower sperm concentration (1 × 106/mL) (Q1: 8.0 vs. Q2: 10.4 vs. Q3: 11.0 vs. Q4: 13.0), total sperm count (1 × 106) (Q1: 29.1 vs. Q2: 38.2 vs. Q3: 44.4 vs. Q4: 55.7), sperm motility (%) (Q1: 41 vs. Q2: 57 vs. Q3: 50 vs. Q4: 53), and progressive sperm motility (%) (Q1: 31 vs. Q2: 44 vs. Q3: 35 vs. Q4: 40) compared with the other quartiles. Moreover, men with a sperm concentration <2 million/mL had a lower serum AMH concentration compared with men having 2–16 × 106 /mL and >16 × 106/mL (31 pmol/L vs. 38 pmol/L vs. 43 pmol/L, respectively). In accordance, men with sperm motility <20% had a lower serum AMH concentration compared with men with sperm motility 20%–42%, and >42% (31 pmol/L vs. 43 pmol/L. vs. 39 pmol/L, respectively). Conclusion: This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility. Clinical Trial Registration Number: NCT05212337
KW - AMH
KW - male infertility
KW - semen quality
U2 - 10.1016/j.fertnstert.2024.03.018
DO - 10.1016/j.fertnstert.2024.03.018
M3 - Journal article
C2 - 38522503
AN - SCOPUS:85190533175
VL - 122
SP - 278
EP - 287
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
IS - 2
ER -
ID: 389509487