Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study
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Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study. / Buchholtz, Poul Erik; Ashkanian, Mahmoud; Hjerrild, Simon; Hauptmann, Line Kirstine; Devantier, Torben Albert; Jensen, Paulina; Wissing, Sanne; Thorgaard, Mette Viller; Bjerager, Laerke; Lund, Julie; Alrø, Anja Johnsen; Speed, Maria Simonsen; Brund, Rene Børge Korsgaard; Videbech, Poul.
I: Acta Neuropsychiatrica, Bind 32, Nr. 6, 2020, s. 328 - 338.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low-frequency rTMS inhibits the anti-depressive effect of ECT.
T2 - A pilot study
AU - Buchholtz, Poul Erik
AU - Ashkanian, Mahmoud
AU - Hjerrild, Simon
AU - Hauptmann, Line Kirstine
AU - Devantier, Torben Albert
AU - Jensen, Paulina
AU - Wissing, Sanne
AU - Thorgaard, Mette Viller
AU - Bjerager, Laerke
AU - Lund, Julie
AU - Alrø, Anja Johnsen
AU - Speed, Maria Simonsen
AU - Brund, Rene Børge Korsgaard
AU - Videbech, Poul
PY - 2020
Y1 - 2020
N2 - OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.METHODS: In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.RESULTS: The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.CONCLUSION: The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.
AB - OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.METHODS: In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.RESULTS: The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.CONCLUSION: The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.
U2 - 10.1017/neu.2020.28
DO - 10.1017/neu.2020.28
M3 - Journal article
C2 - 32713367
VL - 32
SP - 328
EP - 338
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
SN - 0924-2708
IS - 6
ER -
ID: 249816803