TY - JOUR

T1 - Low-dose aspirin or other nonsteroidal anti-inflammatory drug use and prostate cancer risk

T2 - a nationwide study

AU - Skriver, Charlotte

AU - Dehlendorff, Christian

AU - Borre, Michael

AU - Brasso, Klaus

AU - Sørensen, Henrik Toft

AU - Hallas, Jesper

AU - Larsen, Signe Benzon

AU - Tjønneland, Anne

AU - Friis, Søren

PY - 2016/9

Y1 - 2016/9

N2 - PurposeIncreasing evidence suggests that aspirin use may protect against prostate cancer. In a nationwide case–control study, using Danish high-quality registry data, we evaluated the association between the use of low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of prostate cancer.MethodsWe identified 35,600 patients (cases) with histologically verified prostate cancer during 2000–2012. Cases were matched to 177,992 population controls on age and residence by risk-set sampling. Aspirin and nonaspirin NSAID exposure was defined by type, estimated dose, duration, and consistency of use. We used conditional logistic regression to estimate odds ratios (ORs), with 95 % confidence intervals (CIs), for prostate cancer associated with low-dose aspirin (75–150 mg) or nonaspirin NSAID use, adjusted for potential confounders.ResultsUse of low-dose aspirin was associated with an OR for prostate cancer of 0.94 (95 % CI 0.91–0.97). Slightly lower ORs were seen with increasing cumulative amount, duration, and consistency of low-dose aspirin use (continuous use, ≥5 years: OR 0.89; 95 % CI 0.82–0.97; ≥10 years: OR 0.86; 95 % CI 0.70–1.06). Nonaspirin NSAID use was associated with a slightly increased OR for prostate cancer (1.13; 95 % CI 1.10–1.15); however, this association was confined to localized disease and did not vary materially with amount, duration, or consistency of nonaspirin NSAID use.ConclusionsOur study indicates that long-term, consistent low-dose aspirin use may provide modest protection against prostate cancer. The slightly increased risk of only localized prostate cancer with nonaspirin NSAID use suggests a noncausal explanation of the observed association.

AB - PurposeIncreasing evidence suggests that aspirin use may protect against prostate cancer. In a nationwide case–control study, using Danish high-quality registry data, we evaluated the association between the use of low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of prostate cancer.MethodsWe identified 35,600 patients (cases) with histologically verified prostate cancer during 2000–2012. Cases were matched to 177,992 population controls on age and residence by risk-set sampling. Aspirin and nonaspirin NSAID exposure was defined by type, estimated dose, duration, and consistency of use. We used conditional logistic regression to estimate odds ratios (ORs), with 95 % confidence intervals (CIs), for prostate cancer associated with low-dose aspirin (75–150 mg) or nonaspirin NSAID use, adjusted for potential confounders.ResultsUse of low-dose aspirin was associated with an OR for prostate cancer of 0.94 (95 % CI 0.91–0.97). Slightly lower ORs were seen with increasing cumulative amount, duration, and consistency of low-dose aspirin use (continuous use, ≥5 years: OR 0.89; 95 % CI 0.82–0.97; ≥10 years: OR 0.86; 95 % CI 0.70–1.06). Nonaspirin NSAID use was associated with a slightly increased OR for prostate cancer (1.13; 95 % CI 1.10–1.15); however, this association was confined to localized disease and did not vary materially with amount, duration, or consistency of nonaspirin NSAID use.ConclusionsOur study indicates that long-term, consistent low-dose aspirin use may provide modest protection against prostate cancer. The slightly increased risk of only localized prostate cancer with nonaspirin NSAID use suggests a noncausal explanation of the observed association.

KW - Aspirin

KW - Nonsteroidal anti-inflammatory drugs

KW - Prostate neoplasms

KW - Risk

KW - Epidemiology

KW - Casecontrol study

U2 - 10.1007/s10552-016-0785-7

DO - 10.1007/s10552-016-0785-7

M3 - Journal article

C2 - 27503490

VL - 27

SP - 1067

EP - 1079

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

IS - 9

ER -