Low birth weight, adult BMI and inflammation in middle age
Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning › fagfællebedømt
Standard
Low birth weight, adult BMI and inflammation in middle age. / Pedersen, Jolene Lee Masters; Rod, Naja Hulvej; Avlund, Kirsten; Budtz-Jørgensen, Esben; Mortensen, Erik Lykke; Sørensen, Thorkild I.A.; Lund, Rikke.
I: Gerontologist, Bind 53, Nr. suppl. 1, 2013, s. 380.Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - GEN
T1 - Low birth weight, adult BMI and inflammation in middle age
AU - Pedersen, Jolene Lee Masters
AU - Rod, Naja Hulvej
AU - Avlund, Kirsten
AU - Budtz-Jørgensen, Esben
AU - Mortensen, Erik Lykke
AU - Sørensen, Thorkild I.A.
AU - Lund, Rikke
PY - 2013
Y1 - 2013
N2 - This study examines the association between birthweight and adultBMI with inflammation in middle age measured by interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactiveprotein (hsCRP) and tumor necrosis factor alpha (tnf-α). Thestudy is based on participants with continued participation in the CopenhagenPerinatal cohort and Copenhagen Aging and Midlife Biobankclinical examination (n=1,719). Birthweight was negatively associatedwith hsCRP and IL-18.No association was identified with tnf-α, IL-6and IL-10. Adult BMI was positively and significantly associated withall measures of inflammation besides IL-10. Finally, participants in boththe lowest tertile of birthweight and highest tertile of adult BMI hadthe highest levels of all inflammatory markers. Low birthweight andhigh adult BMI are risk factors for inflammation in middle age. Whilethe prenatal period may be sensitive for development of inflammationit appears that modification by adult BMI occurred in this sample.
AB - This study examines the association between birthweight and adultBMI with inflammation in middle age measured by interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactiveprotein (hsCRP) and tumor necrosis factor alpha (tnf-α). Thestudy is based on participants with continued participation in the CopenhagenPerinatal cohort and Copenhagen Aging and Midlife Biobankclinical examination (n=1,719). Birthweight was negatively associatedwith hsCRP and IL-18.No association was identified with tnf-α, IL-6and IL-10. Adult BMI was positively and significantly associated withall measures of inflammation besides IL-10. Finally, participants in boththe lowest tertile of birthweight and highest tertile of adult BMI hadthe highest levels of all inflammatory markers. Low birthweight andhigh adult BMI are risk factors for inflammation in middle age. Whilethe prenatal period may be sensitive for development of inflammationit appears that modification by adult BMI occurred in this sample.
U2 - 10.1093/geront/gnt151
DO - 10.1093/geront/gnt151
M3 - Conference article
VL - 53
SP - 380
JO - The Gerontologist
JF - The Gerontologist
SN - 0016-9013
IS - suppl. 1
ER -
ID: 118448788