Low ABCB1 gene expression is an early event in colorectal carcinogenesis
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Low ABCB1 gene expression is an early event in colorectal carcinogenesis. / Andersen, Vibeke; Vogel, Ulla Birgitte; Godiksen, Sine; Frenzel, Franz B; Sæbø, Mona; Hamfjord, Julian; Kure, Elin; Vogel, Lotte K.
I: PloS one, Bind 8, Nr. 8, 08.2013, s. e72119.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low ABCB1 gene expression is an early event in colorectal carcinogenesis
AU - Andersen, Vibeke
AU - Vogel, Ulla Birgitte
AU - Godiksen, Sine
AU - Frenzel, Franz B
AU - Sæbø, Mona
AU - Hamfjord, Julian
AU - Kure, Elin
AU - Vogel, Lotte K
PY - 2013/8
Y1 - 2013/8
N2 - The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P
AB - The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P
KW - Adenoma
KW - Carcinogenesis
KW - Carcinoma
KW - Case-Control Studies
KW - Colon
KW - Colorectal Neoplasms
KW - Female
KW - Gene Expression
KW - Humans
KW - INDEL Mutation
KW - Male
KW - Middle Aged
KW - NF-kappa B p50 Subunit
KW - P-Glycoprotein
KW - Polymorphism, Single Nucleotide
KW - RNA, Messenger
U2 - 10.1371/journal.pone.0072119
DO - 10.1371/journal.pone.0072119
M3 - Journal article
C2 - 23977225
VL - 8
SP - e72119
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 8
ER -
ID: 108665098