Low 5-HT1B receptor binding in the migraine brain: A PET study
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Low 5-HT1B receptor binding in the migraine brain : A PET study. / Deen, Marie; Hansen, Hanne D; Hougaard, Anders; da Cunha-Bang, Sofi; Nørgaard, Martin; Svarer, Claus; Keller, Sune H; Thomsen, Carsten; Ashina, Messoud; Knudsen, Gitte M.
I: Cephalalgia : an international journal of headache, Bind 38, Nr. 3, 2018, s. 519-527.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low 5-HT1B receptor binding in the migraine brain
T2 - A PET study
AU - Deen, Marie
AU - Hansen, Hanne D
AU - Hougaard, Anders
AU - da Cunha-Bang, Sofi
AU - Nørgaard, Martin
AU - Svarer, Claus
AU - Keller, Sune H
AU - Thomsen, Carsten
AU - Ashina, Messoud
AU - Knudsen, Gitte M
PY - 2018
Y1 - 2018
N2 - Background The pathophysiology of migraine may involve dysfunction of serotonergic signaling. In particular, the 5-HT1B receptor is considered a key player due to the efficacy of 5-HT1B receptor agonists for treatment of migraine attacks. Aim To examine the cerebral 5-HT1B receptor binding in interictal migraine patients without aura compared to controls. Methods Eighteen migraine patients, who had been migraine free for >48 hours, and 16 controls were scanned after injection of the 5-HT1B receptor specific radioligand [11C]AZ10419369 for quantification of cerebral 5-HT1B receptor binding. Patients who reported migraine <48 hours after the PET examination were excluded from the final analysis. We defined seven brain regions involved in pain modulation as regions of interest and applied a latent variable model (LVM) to assess the group effect on binding across these regions. Results Our data support a model wherein group status predicts the latent variable ( p = 0.038), with migraine patients having lower 5-HT1B receptor binding across regions compared to controls. Further, in a whole-brain voxel-based analysis, time since last migraine attack correlated positively with 5-HT1B receptor binding in the dorsal raphe and in the midbrain. Conclusion We report here for the first time that migraine patients have low 5-HT1B receptor binding in pain modulating regions, reflecting decreased receptor density. This is either a primary constitutive trait of the migraine brain or secondary to repeated exposure to migraine attacks. We also provide indirect support for the dorsal raphe 5-HT1B receptors being temporarily downregulated during the migraine attack, presumably in response to higher cerebral serotonin levels in the ictal phase.
AB - Background The pathophysiology of migraine may involve dysfunction of serotonergic signaling. In particular, the 5-HT1B receptor is considered a key player due to the efficacy of 5-HT1B receptor agonists for treatment of migraine attacks. Aim To examine the cerebral 5-HT1B receptor binding in interictal migraine patients without aura compared to controls. Methods Eighteen migraine patients, who had been migraine free for >48 hours, and 16 controls were scanned after injection of the 5-HT1B receptor specific radioligand [11C]AZ10419369 for quantification of cerebral 5-HT1B receptor binding. Patients who reported migraine <48 hours after the PET examination were excluded from the final analysis. We defined seven brain regions involved in pain modulation as regions of interest and applied a latent variable model (LVM) to assess the group effect on binding across these regions. Results Our data support a model wherein group status predicts the latent variable ( p = 0.038), with migraine patients having lower 5-HT1B receptor binding across regions compared to controls. Further, in a whole-brain voxel-based analysis, time since last migraine attack correlated positively with 5-HT1B receptor binding in the dorsal raphe and in the midbrain. Conclusion We report here for the first time that migraine patients have low 5-HT1B receptor binding in pain modulating regions, reflecting decreased receptor density. This is either a primary constitutive trait of the migraine brain or secondary to repeated exposure to migraine attacks. We also provide indirect support for the dorsal raphe 5-HT1B receptors being temporarily downregulated during the migraine attack, presumably in response to higher cerebral serotonin levels in the ictal phase.
KW - Adult
KW - Brain/diagnostic imaging
KW - Female
KW - Humans
KW - Image Interpretation, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Male
KW - Migraine Disorders/diagnostic imaging
KW - Positron-Emission Tomography
KW - Radioligand Assay
KW - Radiopharmaceuticals
KW - Receptor, Serotonin, 5-HT1B/metabolism
U2 - 10.1177/0333102417698708
DO - 10.1177/0333102417698708
M3 - Journal article
C2 - 28730894
VL - 38
SP - 519
EP - 527
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 3
ER -
ID: 215865296