Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice
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Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice. / Grubb, Søren Jahn; Speerschneider, Tobias; Occhipinti, Dona; Fiset, Céline; Olesen, Søren-Peter; Thomsen, Morten Bækgaard; Callø, Kirstine.
I: Journal of Cardiovascular Electrophysiology, Bind 25, Nr. 8, 2014, s. 896-904.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice
AU - Grubb, Søren Jahn
AU - Speerschneider, Tobias
AU - Occhipinti, Dona
AU - Fiset, Céline
AU - Olesen, Søren-Peter
AU - Thomsen, Morten Bækgaard
AU - Callø, Kirstine
N1 - This article is protected by copyright. All rights reserved.
PY - 2014
Y1 - 2014
N2 - KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.
AB - KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.
U2 - 10.1111/jce.12422
DO - 10.1111/jce.12422
M3 - Journal article
C2 - 24678923
VL - 25
SP - 896
EP - 904
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
SN - 1045-3873
IS - 8
ER -
ID: 106948937