Long-term risk of heart failure and other adverse cardiovascular outcomes in primary Sjogren's syndrome
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Long-term risk of heart failure and other adverse cardiovascular outcomes in primary Sjogren's syndrome. / Sun, Guoli; Fosbøl, Emil L.; Yafasova, Adelina; Faurschou, Mikkel; Lindhardsen, Jesper; Torp-Pedersen, Christian; Kober, Lars; Butt, Jawad H.
I: Journal of Internal Medicine, Bind 293, Nr. 4, 2023, s. 457-469.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term risk of heart failure and other adverse cardiovascular outcomes in primary Sjogren's syndrome
AU - Sun, Guoli
AU - Fosbøl, Emil L.
AU - Yafasova, Adelina
AU - Faurschou, Mikkel
AU - Lindhardsen, Jesper
AU - Torp-Pedersen, Christian
AU - Kober, Lars
AU - Butt, Jawad H.
PY - 2023
Y1 - 2023
N2 - BackgroundData on long-term cardiovascular outcomes in primary Sjogren's syndrome (PSS) are scarce. ObjectivesWe aim to investigate the long-term rate of incident heart failure (HF) and other adverse cardiovascular endpoints in patients with PSS compared with the general population and to investigate mortality in individuals with incident HF with or without a history of PSS. MethodsUsing Danish nationwide registries, PSS patients (diagnosed 1996-2018) without a history of other autoimmune diseases were each matched with four individuals from the general population by sex, age, and comorbidities. Multivariable Cox regression was used to estimate the rate of cardiovascular outcomes. In addition, the rate of death from any cause was compared between PSS patients with incident HF and four age- and sex-matched HF patients without PSS. ResultsIn total, 5092 patients with newly diagnosed PSS were matched with 20,368 individuals from the general population (median age 57 years, 87.3% women, median follow-up 7.4 years). The cumulative incidence of HF at 10 years was 4.0% for PSS patients and 2.8% for matched individuals. After adjustment, patients with PSS had a higher associated rate of incident HF (hazard ratios [HR] 1.42 [95% CI, 1.20-1.68]) and other cardiovascular outcomes, compared with the background population. PSS patients with incident HF had a similar rate of death from all-cause mortality compared with HF patients without PSS (HR 0.94 [0.74-1.19]). ConclusionsPatients with PSS had a higher associated rate of incident HF and other cardiovascular outcomes compared with the general population. In individuals with incident HF, a history of PSS was not associated with increased mortality.
AB - BackgroundData on long-term cardiovascular outcomes in primary Sjogren's syndrome (PSS) are scarce. ObjectivesWe aim to investigate the long-term rate of incident heart failure (HF) and other adverse cardiovascular endpoints in patients with PSS compared with the general population and to investigate mortality in individuals with incident HF with or without a history of PSS. MethodsUsing Danish nationwide registries, PSS patients (diagnosed 1996-2018) without a history of other autoimmune diseases were each matched with four individuals from the general population by sex, age, and comorbidities. Multivariable Cox regression was used to estimate the rate of cardiovascular outcomes. In addition, the rate of death from any cause was compared between PSS patients with incident HF and four age- and sex-matched HF patients without PSS. ResultsIn total, 5092 patients with newly diagnosed PSS were matched with 20,368 individuals from the general population (median age 57 years, 87.3% women, median follow-up 7.4 years). The cumulative incidence of HF at 10 years was 4.0% for PSS patients and 2.8% for matched individuals. After adjustment, patients with PSS had a higher associated rate of incident HF (hazard ratios [HR] 1.42 [95% CI, 1.20-1.68]) and other cardiovascular outcomes, compared with the background population. PSS patients with incident HF had a similar rate of death from all-cause mortality compared with HF patients without PSS (HR 0.94 [0.74-1.19]). ConclusionsPatients with PSS had a higher associated rate of incident HF and other cardiovascular outcomes compared with the general population. In individuals with incident HF, a history of PSS was not associated with increased mortality.
KW - cardiovascular outcomes
KW - heart failure
KW - Sjogren's syndrome
KW - MYOCARDIAL-INFARCTION
KW - ASSOCIATION
KW - REGISTRY
KW - BURDEN
U2 - 10.1111/joim.13595
DO - 10.1111/joim.13595
M3 - Journal article
C2 - 36507587
VL - 293
SP - 457
EP - 469
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0955-7873
IS - 4
ER -
ID: 331443583