Long-term prognostic importance of diabetes after a myocardial infarction depends on left ventricular systolic function
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Long-term prognostic importance of diabetes after a myocardial infarction depends on left ventricular systolic function. / Andersson, Charlotte; Gislason, Gunnar H; Mérie, Charlotte; Mogensen, Ulrik M; Solomon, Scott D; Torp-Pedersen, Christian; Køber, Lars.
I: Diabetes Care, Bind 34, Nr. 8, 2011, s. 1788-90.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Long-term prognostic importance of diabetes after a myocardial infarction depends on left ventricular systolic function
AU - Andersson, Charlotte
AU - Gislason, Gunnar H
AU - Mérie, Charlotte
AU - Mogensen, Ulrik M
AU - Solomon, Scott D
AU - Torp-Pedersen, Christian
AU - Køber, Lars
PY - 2011
Y1 - 2011
N2 - This study was performed to understand how left ventricular function modulates the prognostic importance of diabetes after myocardial infarction (MI). RESEARCH DESIGN AND METHODS Consecutively hospitalized MI patients screened for three clinical trials were followed for a median of 7 years. Multivariable Cox regression models were used to assess the risk of mortality associated with diabetes, and the importance of diabetes was examined independently within defined left ventricular ejection fraction (LVEF) subgroups. RESULTS A total of 16,912 patients were included; 1,819 (11%) had diabetes. Diabetes and 15% unit depression in LVEF were of similar prognostic importance: hazard ratios (HRs) were 1.45 (95% CI 1.37–1.54) and 1.41 (1.37–1.45) for diabetes and LVEF depression, respectively. LVEF modified the outcomes associated with diabetes, with HRs being 1.29 (1.19–1.40) and 1.61 (1.49–1.74) in patients with LVEF <40% and LVEF =40%, respectively (P = 0.03). CONCLUSIONS Patients within the higher LVEF categories have a greater mortality risk attributable to diabetes than patients within the lower LVEF categories.
AB - This study was performed to understand how left ventricular function modulates the prognostic importance of diabetes after myocardial infarction (MI). RESEARCH DESIGN AND METHODS Consecutively hospitalized MI patients screened for three clinical trials were followed for a median of 7 years. Multivariable Cox regression models were used to assess the risk of mortality associated with diabetes, and the importance of diabetes was examined independently within defined left ventricular ejection fraction (LVEF) subgroups. RESULTS A total of 16,912 patients were included; 1,819 (11%) had diabetes. Diabetes and 15% unit depression in LVEF were of similar prognostic importance: hazard ratios (HRs) were 1.45 (95% CI 1.37–1.54) and 1.41 (1.37–1.45) for diabetes and LVEF depression, respectively. LVEF modified the outcomes associated with diabetes, with HRs being 1.29 (1.19–1.40) and 1.61 (1.49–1.74) in patients with LVEF <40% and LVEF =40%, respectively (P = 0.03). CONCLUSIONS Patients within the higher LVEF categories have a greater mortality risk attributable to diabetes than patients within the lower LVEF categories.
U2 - 10.2337/dc11-0154
DO - 10.2337/dc11-0154
M3 - Journal article
C2 - 21715523
VL - 34
SP - 1788
EP - 1790
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 8
ER -
ID: 40155537