Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes
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Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes. / Black, E; Holst, C; Astrup, A; Toubro, Søren; Echwald, S; Pedersen, O; Sørensen, Thorkild I.A.
I: Diabetic Medicine, Bind 22, Nr. 9, 2005, s. 1199-1205.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes
AU - Black, E
AU - Holst, C
AU - Astrup, A
AU - Toubro, Søren
AU - Echwald, S
AU - Pedersen, O
AU - Sørensen, Thorkild I.A.
N1 - Keywords: Adult; Aging; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Glucose Intolerance; Glucose Tolerance Test; Humans; Longitudinal Studies; Male; Middle Aged; Obesity; Prevalence; Risk Factors; Weight Gain
PY - 2005
Y1 - 2005
N2 - AIM: To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of attained weight. RESEARCH DESIGN AND METHODS: Data were obtained from a longitudinal study of two cohorts: one of juvenile-onset obese (n = 248) and one of randomly selected control (n = 320) men, weighed at average ages of 20, 33, 44 and 51 years, respectively. RESULTS: For any given BMI, the risk of IGT was higher the greater the weight gain since age 20 (odds ratio of 1.10 per unit kg/m2 of BMI gain, confidence interval 1.03-1.17, P = 0.004), and weight gain during both the early and later ages contributed to the increased risk. Obese men, maintaining weight since age 20, had lower risk of IGT than non-obese men who became similarly obese by age 51. The risk of Type 2 diabetes increased by weight gain in early adult life, but not by more recent weight gain in the later periods, probably because of the development of Type 2 diabetes leading to weight loss. CONCLUSIONS: Independent of attained level of body weight in middle-aged men, weight gain is associated with increased risk of IGT, and is greater in those not overweight in childhood.
AB - AIM: To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of attained weight. RESEARCH DESIGN AND METHODS: Data were obtained from a longitudinal study of two cohorts: one of juvenile-onset obese (n = 248) and one of randomly selected control (n = 320) men, weighed at average ages of 20, 33, 44 and 51 years, respectively. RESULTS: For any given BMI, the risk of IGT was higher the greater the weight gain since age 20 (odds ratio of 1.10 per unit kg/m2 of BMI gain, confidence interval 1.03-1.17, P = 0.004), and weight gain during both the early and later ages contributed to the increased risk. Obese men, maintaining weight since age 20, had lower risk of IGT than non-obese men who became similarly obese by age 51. The risk of Type 2 diabetes increased by weight gain in early adult life, but not by more recent weight gain in the later periods, probably because of the development of Type 2 diabetes leading to weight loss. CONCLUSIONS: Independent of attained level of body weight in middle-aged men, weight gain is associated with increased risk of IGT, and is greater in those not overweight in childhood.
U2 - 10.1111/j.1464-5491.2005.01615.x
DO - 10.1111/j.1464-5491.2005.01615.x
M3 - Journal article
C2 - 16108849
VL - 22
SP - 1199
EP - 1205
JO - Diabetic Medicine
JF - Diabetic Medicine
SN - 0742-3071
IS - 9
ER -
ID: 12389304