Localization of checkpoint and repair proteins in eukaryotes

Publikation: Bidrag til tidsskrift › Review › Forskning

Standard

Localization of checkpoint and repair proteins in eukaryotes. / Lisby, Michael; Rothstein, Rodney.

I: Biochimie, Bind 87, Nr. 7, 2005, s. 579-589.

Publikation: Bidrag til tidsskrift › Review › Forskning

Harvard

Lisby, M & Rothstein, R 2005, 'Localization of checkpoint and repair proteins in eukaryotes', Biochimie, bind 87, nr. 7, s. 579-589. https://doi.org/10.1016/j.biochi.2004.10.023

APA

Lisby, M., & Rothstein, R. (2005). Localization of checkpoint and repair proteins in eukaryotes. Biochimie, 87(7), 579-589. https://doi.org/10.1016/j.biochi.2004.10.023

Vancouver

Lisby M, Rothstein R. Localization of checkpoint and repair proteins in eukaryotes. Biochimie. 2005;87(7):579-589. https://doi.org/10.1016/j.biochi.2004.10.023

Author

Lisby, Michael ; Rothstein, Rodney. / Localization of checkpoint and repair proteins in eukaryotes. I: Biochimie. 2005 ; Bind 87, Nr. 7. s. 579-589.

Bibtex

@article{18fd74b074c311dbbee902004c4f4f50,
title = "Localization of checkpoint and repair proteins in eukaryotes",
abstract = "In eukaryotes, the cellular response to DNA damage depends on the type of DNA structure being recognized by the checkpoint and repair machinery. DNA ends and single-stranded DNA are hallmarks of double-strand breaks and replication stress. These two structures are recognized by distinct sets of proteins, which are reorganized into a focal assembly at the lesion. Moreover, the composition of these foci is coordinated with cell cycle progression, reflecting the favoring of end-joining in the G1 phase and homologous recombination in S and G2. The assembly of proteins at sites of DNA damage is largely controlled by a network of protein-protein interactions, with the Mre11 complex initiating assembly at DNA ends and replication protein A directing recruitment to single-stranded DNA. This review summarizes current knowledge on the cellular organization of DSB repair and checkpoint proteins focusing on budding yeast and mammalian cells.",
author = "Michael Lisby and Rodney Rothstein",
note = "Keywords: Double-strand break; Replication; DNA damage; Checkpoint; Foci; Homologous recombination; Non-homologous end-joining; Repair center",
year = "2005",
doi = "10.1016/j.biochi.2004.10.023",
language = "English",
volume = "87",
pages = "579--589",
journal = "Biochimie",
issn = "0300-9084",
publisher = "Elsevier Masson",
number = "7",

}

RIS

TY - JOUR

T1 - Localization of checkpoint and repair proteins in eukaryotes

AU - Lisby, Michael

AU - Rothstein, Rodney

N1 - Keywords: Double-strand break; Replication; DNA damage; Checkpoint; Foci; Homologous recombination; Non-homologous end-joining; Repair center

PY - 2005

Y1 - 2005

N2 - In eukaryotes, the cellular response to DNA damage depends on the type of DNA structure being recognized by the checkpoint and repair machinery. DNA ends and single-stranded DNA are hallmarks of double-strand breaks and replication stress. These two structures are recognized by distinct sets of proteins, which are reorganized into a focal assembly at the lesion. Moreover, the composition of these foci is coordinated with cell cycle progression, reflecting the favoring of end-joining in the G1 phase and homologous recombination in S and G2. The assembly of proteins at sites of DNA damage is largely controlled by a network of protein-protein interactions, with the Mre11 complex initiating assembly at DNA ends and replication protein A directing recruitment to single-stranded DNA. This review summarizes current knowledge on the cellular organization of DSB repair and checkpoint proteins focusing on budding yeast and mammalian cells.

AB - In eukaryotes, the cellular response to DNA damage depends on the type of DNA structure being recognized by the checkpoint and repair machinery. DNA ends and single-stranded DNA are hallmarks of double-strand breaks and replication stress. These two structures are recognized by distinct sets of proteins, which are reorganized into a focal assembly at the lesion. Moreover, the composition of these foci is coordinated with cell cycle progression, reflecting the favoring of end-joining in the G1 phase and homologous recombination in S and G2. The assembly of proteins at sites of DNA damage is largely controlled by a network of protein-protein interactions, with the Mre11 complex initiating assembly at DNA ends and replication protein A directing recruitment to single-stranded DNA. This review summarizes current knowledge on the cellular organization of DSB repair and checkpoint proteins focusing on budding yeast and mammalian cells.

U2 - 10.1016/j.biochi.2004.10.023

DO - 10.1016/j.biochi.2004.10.023

M3 - Review

C2 - 15989975

VL - 87

SP - 579

EP - 589

JO - Biochimie

JF - Biochimie

SN - 0300-9084

IS - 7

ER -

ID: 86690