Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study.
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Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study. / Christensen, Peer Brehm; Krarup, Henrik Bygum; Møller, Axel; Laursen, Alex Lund; Kjaer, Mette S; Orholm, Marianne; Lindberg, Jens; Groenbaek, Karin; Kromann-Andersen, Hans; Weis, Nina; NN, NN; Weis, Nina.
I: Scandinavian Journal of Infectious Diseases, Bind 39, Nr. 3, 2007, s. 245-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study.
AU - Christensen, Peer Brehm
AU - Krarup, Henrik Bygum
AU - Møller, Axel
AU - Laursen, Alex Lund
AU - Kjaer, Mette S
AU - Orholm, Marianne
AU - Lindberg, Jens
AU - Groenbaek, Karin
AU - Kromann-Andersen, Hans
AU - Weis, Nina
AU - NN, NN
AU - Weis, Nina
PY - 2007
Y1 - 2007
N2 - We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis. Udgivelsesdato: 2007-null
AB - We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis. Udgivelsesdato: 2007-null
U2 - http://dx.doi.org/10.1080/00365540600978864
DO - http://dx.doi.org/10.1080/00365540600978864
M3 - Journal article
VL - 39
SP - 245
EP - 249
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 3
ER -
ID: 34096401