Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals
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Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals. / Søndergaard, Anna; Madsen, Martin Korsbak; Ozenne, Brice; Armand, Sophia; Knudsen, Gitte Moos; Fisher, Patrick MacDonald; Stenbaek, Dea Siggaard.
I: Frontiers in Psychology, Bind 13, 948729, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals
AU - Søndergaard, Anna
AU - Madsen, Martin Korsbak
AU - Ozenne, Brice
AU - Armand, Sophia
AU - Knudsen, Gitte Moos
AU - Fisher, Patrick MacDonald
AU - Stenbaek, Dea Siggaard
PY - 2022
Y1 - 2022
N2 - BackgroundPsilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT2AR) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT2AR binding in the healthy brain. AimWe evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT2AR binding in neocortex and selected frontolimbic regions. Materials and methodsForty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [C-11]-Cimbi-36 positron emission tomography (PET) to assess 5-HT2AR binding in neocortex and, post-hoc, in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex. ResultsThe MAAS score was significantly increased at 3-month follow-up (p = 3.24 x 10(-6)), a change positively associated with the MEQ score (p = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT2AR binding was not significant (p = 0.24), post-hoc analyses revealed a significant negative association between MAAS and right amygdala 5-HT2AR binding (p(FWER) = 0.008). ConclusionWe here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT2AR binding in the right amygdala.
AB - BackgroundPsilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT2AR) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT2AR binding in the healthy brain. AimWe evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT2AR binding in neocortex and selected frontolimbic regions. Materials and methodsForty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [C-11]-Cimbi-36 positron emission tomography (PET) to assess 5-HT2AR binding in neocortex and, post-hoc, in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex. ResultsThe MAAS score was significantly increased at 3-month follow-up (p = 3.24 x 10(-6)), a change positively associated with the MEQ score (p = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT2AR binding was not significant (p = 0.24), post-hoc analyses revealed a significant negative association between MAAS and right amygdala 5-HT2AR binding (p(FWER) = 0.008). ConclusionWe here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT2AR binding in the right amygdala.
KW - psilocybin
KW - mindfulness
KW - psychedelics
KW - mystical experience
KW - serotonin 2A receptor
KW - [C-11]-Cimbi-36
KW - Mindful Attention and Awareness Scale
KW - LIFE-THREATENING CANCER
KW - RECEPTOR-BINDING
KW - PSYCHOLOGICAL HEALTH
KW - COMMITMENT THERAPY
KW - HUMAN BRAIN
KW - MEDITATION
KW - 5-HT2A
KW - VALIDATION
KW - DEPRESSION
KW - ANXIETY
U2 - 10.3389/fpsyg.2022.948729
DO - 10.3389/fpsyg.2022.948729
M3 - Journal article
C2 - 36275302
VL - 13
JO - Frontiers in Psychology
JF - Frontiers in Psychology
SN - 1664-1078
M1 - 948729
ER -
ID: 324421740