TY - JOUR

T1 - Lack of association between the MTHFR (C677T) polymorphism and atopic disease

AU - Thuesen, Betina Heinsbaek

AU - Husemoen, Lise Lotte Nystrup

AU - Fenger, Mogens

AU - Linneberg, Allan

AU - Thuesen, Betina Heinsbaek

AU - Husemoen, Lise Lotte Nystrup

AU - Fenger, Mogens

N1 - Keywords: Adolescent; Adult; Aged; Asthma; Biological Markers; Bronchial Hyperreactivity; Cohort Studies; Confidence Intervals; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Hypersensitivity, Immediate; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymorphism, Genetic; Rhinitis, Allergic, Seasonal; Risk Assessment; Sampling Studies; Sensitivity and Specificity; Young Adult

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Impaired folate metabolism has been suggested as a potential risk factor for the development of asthma and atopic disease. However, there have been conflicting reports on the potential association between atopic disease and a common polymorphism of the methylene-tetrahydrofolate reductase (MTHFR)-gene, a well-known marker of impaired folate metabolism. OBJECTIVES: The aim of this study was to investigate the association between the MTHFR (C677T) polymorphism and different outcome variables of asthma and atopic disease. METHODS: This study was a population-based study of 1189 participants aged 15-77 years living in Copenhagen, the Capital of Denmark. Examinations included measurements of specific IgE and skin prick tests against inhalant allergens, metacholine bronchial hyper-reactivity, and serum eosinophilic cationic protein, and a self-administered questionnaire about diagnoses and symptoms of allergy and asthma. In addition, participants were genotyped for the MTHFR (C677T) polymorphism. RESULTS: None of the examined outcomes were significantly associated with the MTHFR (C677T) polymorphism. CONCLUSIONS: The results of this study using detailed objective markers of atopic disease do not support the hypothesis that impaired folate metabolism as reflected by the MTHFR genotype is involved in the development of atopic disease.

AB - BACKGROUND: Impaired folate metabolism has been suggested as a potential risk factor for the development of asthma and atopic disease. However, there have been conflicting reports on the potential association between atopic disease and a common polymorphism of the methylene-tetrahydrofolate reductase (MTHFR)-gene, a well-known marker of impaired folate metabolism. OBJECTIVES: The aim of this study was to investigate the association between the MTHFR (C677T) polymorphism and different outcome variables of asthma and atopic disease. METHODS: This study was a population-based study of 1189 participants aged 15-77 years living in Copenhagen, the Capital of Denmark. Examinations included measurements of specific IgE and skin prick tests against inhalant allergens, metacholine bronchial hyper-reactivity, and serum eosinophilic cationic protein, and a self-administered questionnaire about diagnoses and symptoms of allergy and asthma. In addition, participants were genotyped for the MTHFR (C677T) polymorphism. RESULTS: None of the examined outcomes were significantly associated with the MTHFR (C677T) polymorphism. CONCLUSIONS: The results of this study using detailed objective markers of atopic disease do not support the hypothesis that impaired folate metabolism as reflected by the MTHFR genotype is involved in the development of atopic disease.

U2 - 10.1111/j.1752-699X.2009.00128.x

DO - 10.1111/j.1752-699X.2009.00128.x

M3 - Journal article

C2 - 20298385

VL - 3

SP - 102

EP - 108

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

IS - 2

ER -