Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

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Standard

Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. / Lee, M. R.; Shnitko, T. A.; Blue, S. W.; Kaucher, A. V.; Winchell, A. J.; Erikson, D. W.; Grant, K. A.; Leggio, L.

I: Nature Communications, 12.2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lee, MR, Shnitko, TA, Blue, SW, Kaucher, AV, Winchell, AJ, Erikson, DW, Grant, KA & Leggio, L 2020, 'Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques', Nature Communications. https://doi.org/10.1038/s41467-020-15942-1

APA

Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., & Leggio, L. (2020). Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. Nature Communications, [2783]. https://doi.org/10.1038/s41467-020-15942-1

Vancouver

Lee MR, Shnitko TA, Blue SW, Kaucher AV, Winchell AJ, Erikson DW o.a. Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. Nature Communications. 2020 dec. 2783. https://doi.org/10.1038/s41467-020-15942-1

Author

Lee, M. R. ; Shnitko, T. A. ; Blue, S. W. ; Kaucher, A. V. ; Winchell, A. J. ; Erikson, D. W. ; Grant, K. A. ; Leggio, L. / Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. I: Nature Communications. 2020.

Bibtex

@article{cfc76f6d1c0543e6bdd1815316d80b21,
title = "Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques",
abstract = "Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date, the brain tissue penetrance of intranasal oxytocin has not been demonstrated. In this nonhuman primate study, we administer deuterated oxytocin intranasally and intravenously to rhesus macaques and measure, with mass spectrometry, concentrations of labeled (exogenously administered) and endogenous oxytocin in 12 brain regions two hours after oxytocin administration. Labeled oxytocin is quantified after intranasal (not intravenous) administration in brain regions (orbitofrontal cortex, striatum, brainstem, and thalamus) that lie in the trajectories of the olfactory and trigeminal nerves. These results suggest that intranasal administration bypasses the blood–brain barrier, delivering oxytocin to specific brain regions, such as the striatum, where oxytocin acts to impact motivated behaviors. Further, high concentrations of endogenous oxytocin are in regions that overlap with projection fields of oxytocinergic neurons.",
author = "Lee, {M. R.} and Shnitko, {T. A.} and Blue, {S. W.} and Kaucher, {A. V.} and Winchell, {A. J.} and Erikson, {D. W.} and Grant, {K. A.} and L. Leggio",
year = "2020",
month = dec,
doi = "10.1038/s41467-020-15942-1",
language = "English",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

AU - Lee, M. R.

AU - Shnitko, T. A.

AU - Blue, S. W.

AU - Kaucher, A. V.

AU - Winchell, A. J.

AU - Erikson, D. W.

AU - Grant, K. A.

AU - Leggio, L.

PY - 2020/12

Y1 - 2020/12

N2 - Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date, the brain tissue penetrance of intranasal oxytocin has not been demonstrated. In this nonhuman primate study, we administer deuterated oxytocin intranasally and intravenously to rhesus macaques and measure, with mass spectrometry, concentrations of labeled (exogenously administered) and endogenous oxytocin in 12 brain regions two hours after oxytocin administration. Labeled oxytocin is quantified after intranasal (not intravenous) administration in brain regions (orbitofrontal cortex, striatum, brainstem, and thalamus) that lie in the trajectories of the olfactory and trigeminal nerves. These results suggest that intranasal administration bypasses the blood–brain barrier, delivering oxytocin to specific brain regions, such as the striatum, where oxytocin acts to impact motivated behaviors. Further, high concentrations of endogenous oxytocin are in regions that overlap with projection fields of oxytocinergic neurons.

AB - Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date, the brain tissue penetrance of intranasal oxytocin has not been demonstrated. In this nonhuman primate study, we administer deuterated oxytocin intranasally and intravenously to rhesus macaques and measure, with mass spectrometry, concentrations of labeled (exogenously administered) and endogenous oxytocin in 12 brain regions two hours after oxytocin administration. Labeled oxytocin is quantified after intranasal (not intravenous) administration in brain regions (orbitofrontal cortex, striatum, brainstem, and thalamus) that lie in the trajectories of the olfactory and trigeminal nerves. These results suggest that intranasal administration bypasses the blood–brain barrier, delivering oxytocin to specific brain regions, such as the striatum, where oxytocin acts to impact motivated behaviors. Further, high concentrations of endogenous oxytocin are in regions that overlap with projection fields of oxytocinergic neurons.

U2 - 10.1038/s41467-020-15942-1

DO - 10.1038/s41467-020-15942-1

M3 - Journal article

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2783

ER -

ID: 301735133