Knocking out IL-6 by vaccination

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Standard

Knocking out IL-6 by vaccination. / Galle, Pia; Hougs, Lotte; Barington, Torben; Svenson, Morten; Svejgaard, Arne; Thomsen, Allan Randrup; Bendtzen, Klaus; Hansen, Morten B.

I: European Journal of Immunology, Bind 34, Nr. 1, 2004, s. 291-300.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Galle, P, Hougs, L, Barington, T, Svenson, M, Svejgaard, A, Thomsen, AR, Bendtzen, K & Hansen, MB 2004, 'Knocking out IL-6 by vaccination', European Journal of Immunology, bind 34, nr. 1, s. 291-300. https://doi.org/10.1002/eji.200324338

APA

Galle, P., Hougs, L., Barington, T., Svenson, M., Svejgaard, A., Thomsen, A. R., Bendtzen, K., & Hansen, M. B. (2004). Knocking out IL-6 by vaccination. European Journal of Immunology, 34(1), 291-300. https://doi.org/10.1002/eji.200324338

Vancouver

Galle P, Hougs L, Barington T, Svenson M, Svejgaard A, Thomsen AR o.a. Knocking out IL-6 by vaccination. European Journal of Immunology. 2004;34(1):291-300. https://doi.org/10.1002/eji.200324338

Author

Galle, Pia ; Hougs, Lotte ; Barington, Torben ; Svenson, Morten ; Svejgaard, Arne ; Thomsen, Allan Randrup ; Bendtzen, Klaus ; Hansen, Morten B. / Knocking out IL-6 by vaccination. I: European Journal of Immunology. 2004 ; Bind 34, Nr. 1. s. 291-300.

Bibtex

@article{910ae1f0e16c11ddb5fc000ea68e967b,
title = "Knocking out IL-6 by vaccination",
abstract = "Inappropriate expression of IL-6 plays a role in various inflammatory conditions, degenerative diseases, and cancers. Several model systems have been developed that can specifically block IL-6-receptor interactions. Here we present a simple and highly effective approach based on vaccination with a pool of specifically mutated IL-6 analogues to induce a neutralizing IL-6 antibody response in mice. Judged by the ability of the analogues to bind to heterologous anti-IL-6 antibodies and cellular IL-6 receptors the IL-6 analogues seemed to have a three-dimensional structure comparable to that of wild-type IL-6. Injection of them broke self-tolerance and induced an immune response to IL-6, presumably because of the amino acid differences between the analogues and wild-type IL-6. This resulted in a long-lasting anti-IL-6 antibody-mediated IL-6 deficiency that blocked experimentally induced IL-6-mediated pathology.",
author = "Pia Galle and Lotte Hougs and Torben Barington and Morten Svenson and Arne Svejgaard and Thomsen, {Allan Randrup} and Klaus Bendtzen and Hansen, {Morten B}",
note = "Keywords: Amino Acid Sequence; Animals; Antibodies; Female; Humans; Interleukin-6; Mice; Molecular Sequence Data; Protein Structure, Tertiary; Vaccines",
year = "2004",
doi = "10.1002/eji.200324338",
language = "English",
volume = "34",
pages = "291--300",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "1",

}

RIS

TY - JOUR

T1 - Knocking out IL-6 by vaccination

AU - Galle, Pia

AU - Hougs, Lotte

AU - Barington, Torben

AU - Svenson, Morten

AU - Svejgaard, Arne

AU - Thomsen, Allan Randrup

AU - Bendtzen, Klaus

AU - Hansen, Morten B

N1 - Keywords: Amino Acid Sequence; Animals; Antibodies; Female; Humans; Interleukin-6; Mice; Molecular Sequence Data; Protein Structure, Tertiary; Vaccines

PY - 2004

Y1 - 2004

N2 - Inappropriate expression of IL-6 plays a role in various inflammatory conditions, degenerative diseases, and cancers. Several model systems have been developed that can specifically block IL-6-receptor interactions. Here we present a simple and highly effective approach based on vaccination with a pool of specifically mutated IL-6 analogues to induce a neutralizing IL-6 antibody response in mice. Judged by the ability of the analogues to bind to heterologous anti-IL-6 antibodies and cellular IL-6 receptors the IL-6 analogues seemed to have a three-dimensional structure comparable to that of wild-type IL-6. Injection of them broke self-tolerance and induced an immune response to IL-6, presumably because of the amino acid differences between the analogues and wild-type IL-6. This resulted in a long-lasting anti-IL-6 antibody-mediated IL-6 deficiency that blocked experimentally induced IL-6-mediated pathology.

AB - Inappropriate expression of IL-6 plays a role in various inflammatory conditions, degenerative diseases, and cancers. Several model systems have been developed that can specifically block IL-6-receptor interactions. Here we present a simple and highly effective approach based on vaccination with a pool of specifically mutated IL-6 analogues to induce a neutralizing IL-6 antibody response in mice. Judged by the ability of the analogues to bind to heterologous anti-IL-6 antibodies and cellular IL-6 receptors the IL-6 analogues seemed to have a three-dimensional structure comparable to that of wild-type IL-6. Injection of them broke self-tolerance and induced an immune response to IL-6, presumably because of the amino acid differences between the analogues and wild-type IL-6. This resulted in a long-lasting anti-IL-6 antibody-mediated IL-6 deficiency that blocked experimentally induced IL-6-mediated pathology.

U2 - 10.1002/eji.200324338

DO - 10.1002/eji.200324338

M3 - Journal article

C2 - 14971055

VL - 34

SP - 291

EP - 300

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 1

ER -

ID: 9701330