Kinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from living mice
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Kinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from living mice. / Lauritzen, Hans Peter M. Mortensen; Galbo, Henrik; Toyoda, Taro; Goodyear, Laurie J.
I: Diabetes, Bind 59, Nr. 9, 01.09.2010, s. 2134-44.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Kinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from living mice
AU - Lauritzen, Hans Peter M. Mortensen
AU - Galbo, Henrik
AU - Toyoda, Taro
AU - Goodyear, Laurie J
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood. The purpose of this study was to 1) use a novel imaging system to elucidate the kinetics of contraction-induced GLUT4 translocation in skeletal muscle and 2) determine the function of AMP-activated protein kinase alpha2 (AMPKalpha2) in this process.
AB - Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood. The purpose of this study was to 1) use a novel imaging system to elucidate the kinetics of contraction-induced GLUT4 translocation in skeletal muscle and 2) determine the function of AMP-activated protein kinase alpha2 (AMPKalpha2) in this process.
U2 - http://dx.doi.org/10.2337/db10-0233
DO - http://dx.doi.org/10.2337/db10-0233
M3 - Journal article
VL - 59
SP - 2134
EP - 2144
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 9
ER -
ID: 34109514