Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. / Wiers, Corinde E.; Vendruscolo, Leandro F.; van der Veen, Jan Willem; Manza, Peter; Shokri-Kojori, Ehsan; Kroll, Danielle S.; Feldman, Dana E.; McPherson, Katherine L.; Biesecker, Catherine L.; Zhang, Rui; Herman, Kimberly; Elvig, Sophie K.; Vendruscolo, Janaina C.M.; Turner, Sara A.; Yang, Shanna; Schwandt, Melanie; Tomasi, Dardo; Cervenka, Mackenzie C.; Fink-Jensen, Anders; Benveniste, Helene; Diazgranados, Nancy; Wang, Gene Jack; Koob, George F.; Volkow, Nora D.

I: Science Advances, Bind 7, Nr. 15, eabf6780, 09.04.2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wiers, CE, Vendruscolo, LF, van der Veen, JW, Manza, P, Shokri-Kojori, E, Kroll, DS, Feldman, DE, McPherson, KL, Biesecker, CL, Zhang, R, Herman, K, Elvig, SK, Vendruscolo, JCM, Turner, SA, Yang, S, Schwandt, M, Tomasi, D, Cervenka, MC, Fink-Jensen, A, Benveniste, H, Diazgranados, N, Wang, GJ, Koob, GF & Volkow, ND 2021, 'Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents', Science Advances, bind 7, nr. 15, eabf6780. https://doi.org/10.1126/SCIADV.ABF6780

APA

Wiers, C. E., Vendruscolo, L. F., van der Veen, J. W., Manza, P., Shokri-Kojori, E., Kroll, D. S., Feldman, D. E., McPherson, K. L., Biesecker, C. L., Zhang, R., Herman, K., Elvig, S. K., Vendruscolo, J. C. M., Turner, S. A., Yang, S., Schwandt, M., Tomasi, D., Cervenka, M. C., Fink-Jensen, A., ... Volkow, N. D. (2021). Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. Science Advances, 7(15), [eabf6780]. https://doi.org/10.1126/SCIADV.ABF6780

Vancouver

Wiers CE, Vendruscolo LF, van der Veen JW, Manza P, Shokri-Kojori E, Kroll DS o.a. Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. Science Advances. 2021 apr. 9;7(15). eabf6780. https://doi.org/10.1126/SCIADV.ABF6780

Author

Wiers, Corinde E. ; Vendruscolo, Leandro F. ; van der Veen, Jan Willem ; Manza, Peter ; Shokri-Kojori, Ehsan ; Kroll, Danielle S. ; Feldman, Dana E. ; McPherson, Katherine L. ; Biesecker, Catherine L. ; Zhang, Rui ; Herman, Kimberly ; Elvig, Sophie K. ; Vendruscolo, Janaina C.M. ; Turner, Sara A. ; Yang, Shanna ; Schwandt, Melanie ; Tomasi, Dardo ; Cervenka, Mackenzie C. ; Fink-Jensen, Anders ; Benveniste, Helene ; Diazgranados, Nancy ; Wang, Gene Jack ; Koob, George F. ; Volkow, Nora D. / Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. I: Science Advances. 2021 ; Bind 7, Nr. 15.

Bibtex

@article{c9f1abc616e6491fb6c7e7a6b9216901,

title = "Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents",

abstract = "Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower “wanting” and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.",

author = "Wiers, {Corinde E.} and Vendruscolo, {Leandro F.} and {van der Veen}, {Jan Willem} and Peter Manza and Ehsan Shokri-Kojori and Kroll, {Danielle S.} and Feldman, {Dana E.} and McPherson, {Katherine L.} and Biesecker, {Catherine L.} and Rui Zhang and Kimberly Herman and Elvig, {Sophie K.} and Vendruscolo, {Janaina C.M.} and Turner, {Sara A.} and Shanna Yang and Melanie Schwandt and Dardo Tomasi and Cervenka, {Mackenzie C.} and Anders Fink-Jensen and Helene Benveniste and Nancy Diazgranados and Wang, {Gene Jack} and Koob, {George F.} and Volkow, {Nora D.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).",

year = "2021",

month = apr,

day = "9",

doi = "10.1126/SCIADV.ABF6780",

language = "English",

volume = "7",

journal = "Science advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "15",

}

RIS

TY - JOUR

T1 - Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents

AU - Wiers, Corinde E.

AU - Vendruscolo, Leandro F.

AU - van der Veen, Jan Willem

AU - Manza, Peter

AU - Shokri-Kojori, Ehsan

AU - Kroll, Danielle S.

AU - Feldman, Dana E.

AU - McPherson, Katherine L.

AU - Biesecker, Catherine L.

AU - Zhang, Rui

AU - Herman, Kimberly

AU - Elvig, Sophie K.

AU - Vendruscolo, Janaina C.M.

AU - Turner, Sara A.

AU - Yang, Shanna

AU - Schwandt, Melanie

AU - Tomasi, Dardo

AU - Cervenka, Mackenzie C.

AU - Fink-Jensen, Anders

AU - Benveniste, Helene

AU - Diazgranados, Nancy

AU - Wang, Gene Jack

AU - Koob, George F.

AU - Volkow, Nora D.

N1 - Publisher Copyright: © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

PY - 2021/4/9

Y1 - 2021/4/9

N2 - Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower “wanting” and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.

AB - Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower “wanting” and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.

U2 - 10.1126/SCIADV.ABF6780

DO - 10.1126/SCIADV.ABF6780

M3 - Journal article

C2 - 33837086

AN - SCOPUS:85104211071

VL - 7

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 15

M1 - eabf6780

ER -

ID: 280674810