Karmitoxin: an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

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Standard

Karmitoxin : an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger. / Rasmussen, Silas Anselm; Binzer, Sofie Bjørnholt; Hoeck, Casper; Meier, Sebastian; Soman de Medeiros, Lívia; Andersen, Nikolaj Gedsted; Place, Allen; Nielsen, Kristian Fog; Hansen, Per Juel; Larsen, Thomas Ostenfeld.

I: Journal of Natural Products, Bind 80, Nr. 5, 05.04.2017, s. 1287−1293.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, SA, Binzer, SB, Hoeck, C, Meier, S, Soman de Medeiros, L, Andersen, NG, Place, A, Nielsen, KF, Hansen, PJ & Larsen, TO 2017, 'Karmitoxin: an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger', Journal of Natural Products, bind 80, nr. 5, s. 1287−1293. https://doi.org/10.1021/acs.jnatprod.6b00860

APA

Rasmussen, S. A., Binzer, S. B., Hoeck, C., Meier, S., Soman de Medeiros, L., Andersen, N. G., Place, A., Nielsen, K. F., Hansen, P. J., & Larsen, T. O. (2017). Karmitoxin: an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger. Journal of Natural Products, 80(5), 1287−1293. https://doi.org/10.1021/acs.jnatprod.6b00860

Vancouver

Rasmussen SA, Binzer SB, Hoeck C, Meier S, Soman de Medeiros L, Andersen NG o.a. Karmitoxin: an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger. Journal of Natural Products. 2017 apr. 5;80(5):1287−1293. https://doi.org/10.1021/acs.jnatprod.6b00860

Author

Rasmussen, Silas Anselm ; Binzer, Sofie Bjørnholt ; Hoeck, Casper ; Meier, Sebastian ; Soman de Medeiros, Lívia ; Andersen, Nikolaj Gedsted ; Place, Allen ; Nielsen, Kristian Fog ; Hansen, Per Juel ; Larsen, Thomas Ostenfeld. / Karmitoxin : an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger. I: Journal of Natural Products. 2017 ; Bind 80, Nr. 5. s. 1287−1293.

Bibtex

@article{7e257cc6e55241fa942363a4cc5843c4,
title = "Karmitoxin: an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger",
abstract = "Marine algae from the genus Karlodinium are known to be involved in fish-killing events worldwide. Here we report for the first time the chemistry and bioactivity of a natural product from the newly described mixotrophicdinoflagellate Karlodinium armiger. Our work describes the isolation and structural characterization of a new polyhydroxypolyene named karmitoxin. The structure elucidation work was facilitated by use of 13C enrichment and high-field 2D NMR spectroscopy, where 1H−13C long-range correlations turned out to be very informative. Karmitoxin is structurally related to amphidinols and karlotoxins; however it differs by containing the longest carbon−carbon backbone discovered for this class of compounds, as well as a primary amino group.Karmitoxin showed potent nanomolar cytotoxic activity in an RTgill-W1 cell assay as well as rapid immobilization and eventualmortality of the copepod Acartia tonsa, a natural grazer of K. armiger.",
author = "Rasmussen, {Silas Anselm} and Binzer, {Sofie Bj{\o}rnholt} and Casper Hoeck and Sebastian Meier and {Soman de Medeiros}, L{\'i}via and Andersen, {Nikolaj Gedsted} and Allen Place and Nielsen, {Kristian Fog} and Hansen, {Per Juel} and Larsen, {Thomas Ostenfeld}",
year = "2017",
month = apr,
day = "5",
doi = "10.1021/acs.jnatprod.6b00860",
language = "English",
volume = "80",
pages = "1287−1293",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - Karmitoxin

T2 - an amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

AU - Rasmussen, Silas Anselm

AU - Binzer, Sofie Bjørnholt

AU - Hoeck, Casper

AU - Meier, Sebastian

AU - Soman de Medeiros, Lívia

AU - Andersen, Nikolaj Gedsted

AU - Place, Allen

AU - Nielsen, Kristian Fog

AU - Hansen, Per Juel

AU - Larsen, Thomas Ostenfeld

PY - 2017/4/5

Y1 - 2017/4/5

N2 - Marine algae from the genus Karlodinium are known to be involved in fish-killing events worldwide. Here we report for the first time the chemistry and bioactivity of a natural product from the newly described mixotrophicdinoflagellate Karlodinium armiger. Our work describes the isolation and structural characterization of a new polyhydroxypolyene named karmitoxin. The structure elucidation work was facilitated by use of 13C enrichment and high-field 2D NMR spectroscopy, where 1H−13C long-range correlations turned out to be very informative. Karmitoxin is structurally related to amphidinols and karlotoxins; however it differs by containing the longest carbon−carbon backbone discovered for this class of compounds, as well as a primary amino group.Karmitoxin showed potent nanomolar cytotoxic activity in an RTgill-W1 cell assay as well as rapid immobilization and eventualmortality of the copepod Acartia tonsa, a natural grazer of K. armiger.

AB - Marine algae from the genus Karlodinium are known to be involved in fish-killing events worldwide. Here we report for the first time the chemistry and bioactivity of a natural product from the newly described mixotrophicdinoflagellate Karlodinium armiger. Our work describes the isolation and structural characterization of a new polyhydroxypolyene named karmitoxin. The structure elucidation work was facilitated by use of 13C enrichment and high-field 2D NMR spectroscopy, where 1H−13C long-range correlations turned out to be very informative. Karmitoxin is structurally related to amphidinols and karlotoxins; however it differs by containing the longest carbon−carbon backbone discovered for this class of compounds, as well as a primary amino group.Karmitoxin showed potent nanomolar cytotoxic activity in an RTgill-W1 cell assay as well as rapid immobilization and eventualmortality of the copepod Acartia tonsa, a natural grazer of K. armiger.

U2 - 10.1021/acs.jnatprod.6b00860

DO - 10.1021/acs.jnatprod.6b00860

M3 - Journal article

C2 - 28379705

VL - 80

SP - 1287−1293

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -

ID: 174459466