IVIG as a Promising Therapy for Methotrexate-induced Life-threatening Neutropenic Enterocolitis in an Elderly Patient With Rheumatoid Arthritis: A Case Report and Literature Review
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IVIG as a Promising Therapy for Methotrexate-induced Life-threatening Neutropenic Enterocolitis in an Elderly Patient With Rheumatoid Arthritis : A Case Report and Literature Review. / Lui, Shan Wen; Lu, Jeng Wei; Ho, Yi Jung; Hsieh, Ting Yu; Yeh, Fu Chiang; Liu, Feng Cheng.
I: In Vivo, Bind 38, 2024, s. 511-517.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - IVIG as a Promising Therapy for Methotrexate-induced Life-threatening Neutropenic Enterocolitis in an Elderly Patient With Rheumatoid Arthritis
T2 - A Case Report and Literature Review
AU - Lui, Shan Wen
AU - Lu, Jeng Wei
AU - Ho, Yi Jung
AU - Hsieh, Ting Yu
AU - Yeh, Fu Chiang
AU - Liu, Feng Cheng
N1 - Publisher Copyright: Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2024
Y1 - 2024
N2 - BACKGROUND/AIM: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with the functional impairment of multiple joints and the destruction of bone and cartilage. Methotrexate (MTX) is a first-line drug commonly used to treat RA; however, even low doses of MTX can potentially cause rare but severe adverse reactions, such as neutropenic enterocolitis (NE), a life-threatening disease characterized by intestinal mucosal damage and immunodeficiency. CASE REPORT: Here, we report on an 82-year-old RA patient who developed life-threatening NE after ten years of low-dose MTX treatment. The condition of the patient rapidly worsened, requiring emergency electrical cardioversion and intravenous treatment with immunoglobulin (IVIG). Immunophenotypic responses were analyzed before and after treatment to evaluate therapeutic efficacy. CONCLUSION: This case highlights the importance of monitoring elderly patients with RA receiving low-dose MTX treatment for the potential accumulation of MTX toxicity. Our findings also illustrate the importance of providing timely IVIG therapy for MTX-induced NE.
AB - BACKGROUND/AIM: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with the functional impairment of multiple joints and the destruction of bone and cartilage. Methotrexate (MTX) is a first-line drug commonly used to treat RA; however, even low doses of MTX can potentially cause rare but severe adverse reactions, such as neutropenic enterocolitis (NE), a life-threatening disease characterized by intestinal mucosal damage and immunodeficiency. CASE REPORT: Here, we report on an 82-year-old RA patient who developed life-threatening NE after ten years of low-dose MTX treatment. The condition of the patient rapidly worsened, requiring emergency electrical cardioversion and intravenous treatment with immunoglobulin (IVIG). Immunophenotypic responses were analyzed before and after treatment to evaluate therapeutic efficacy. CONCLUSION: This case highlights the importance of monitoring elderly patients with RA receiving low-dose MTX treatment for the potential accumulation of MTX toxicity. Our findings also illustrate the importance of providing timely IVIG therapy for MTX-induced NE.
KW - Case report
KW - methotrexate
KW - neutropenia
KW - neutropenic enterocolitis
KW - rheumatoid arthritis
U2 - 10.21873/invivo.13468
DO - 10.21873/invivo.13468
M3 - Journal article
C2 - 38148101
AN - SCOPUS:85180846188
VL - 38
SP - 511
EP - 517
JO - In Vivo
JF - In Vivo
SN - 0258-851X
ER -
ID: 379589609