Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Bioactivity directed fractionation of the chloroform extract of the root bark of Maytenus senegalensis resulted in the isolation and characterization of the quinonemethide triterpene, (20α)-3-hydroxy-2-oxo-24-nor-friedela-1(10) ,3,5,7-tetraen-carboxylic acid-(29)-methylester (pristimerin). The structure was elucidated by spectroscopic techniques. The in vitro antiplasmodial activity of the isolated compound against chloroquine-resistant strain (Dd2) of Plasmodium falciparum was IC50 = 0.5μg/ml and its in vitro antileishmanial activity performed on promostigotes of Leishmania major was IC50 = 6.8 ± 0.8 μg/ml while the cytotoxicity on lymphocyte proliferation model was detected at IC50= 6.8 ± 0.8 μg/ml.
Originalsprog | Engelsk |
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Tidsskrift | ARKIVOC |
Vol/bind | 2007 |
Udgave nummer | 9 |
Sider (fra-til) | 129-134 |
Antal sider | 6 |
ISSN | 1551-7012 |
DOI | |
Status | Udgivet - 29 jan. 2007 |
ID: 232592782