Isolation and characterization of novel plasmid-dependent phages infecting bacteria carrying diverse conjugative plasmids
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Isolation and characterization of novel plasmid-dependent phages infecting bacteria carrying diverse conjugative plasmids. / Parra, Boris; Cockx, Bastiaan; Lutz, Veronika T.; Brøndsted, Lone; Smets, Barth F.; Dechesne, Arnaud.
I: Microbiology Spectrum, Bind 12, Nr. 1, 2024, s. e0253723.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Isolation and characterization of novel plasmid-dependent phages infecting bacteria carrying diverse conjugative plasmids
AU - Parra, Boris
AU - Cockx, Bastiaan
AU - Lutz, Veronika T.
AU - Brøndsted, Lone
AU - Smets, Barth F.
AU - Dechesne, Arnaud
PY - 2024
Y1 - 2024
N2 - IMPORTANCE: This work was undertaken because plasmid-dependent phages can reduce the prevalence of conjugative plasmids and can be leveraged to prevent the acquisition and dissemination of ARGs by bacteria. The two novel phages described in this study, Lu221 and Hi226, can infect Escherichia coli, Salmonella enterica, Kluyvera sp. and Enterobacter sp. carrying conjugative plasmids. This was verified with plasmids carrying resistance determinants and belonging to the most common plasmid families among Gram-negative pathogens. Therefore, the newly isolated phages could have the potential to help control the spread of ARGs and thus help combat the antimicrobial resistance crisis.
AB - IMPORTANCE: This work was undertaken because plasmid-dependent phages can reduce the prevalence of conjugative plasmids and can be leveraged to prevent the acquisition and dissemination of ARGs by bacteria. The two novel phages described in this study, Lu221 and Hi226, can infect Escherichia coli, Salmonella enterica, Kluyvera sp. and Enterobacter sp. carrying conjugative plasmids. This was verified with plasmids carrying resistance determinants and belonging to the most common plasmid families among Gram-negative pathogens. Therefore, the newly isolated phages could have the potential to help control the spread of ARGs and thus help combat the antimicrobial resistance crisis.
KW - antimicrobial resistance
KW - bacteriophages
KW - Caudoviricetes
KW - conjugation
KW - horizontal gene transfer
KW - pilus
KW - wastewater
U2 - 10.1128/spectrum.02537-23
DO - 10.1128/spectrum.02537-23
M3 - Journal article
C2 - 38063386
AN - SCOPUS:85182500844
VL - 12
SP - e0253723
JO - Microbiology spectrum
JF - Microbiology spectrum
SN - 2165-0497
IS - 1
ER -
ID: 380656425