Is better preservation of eccentric strength after stroke due to altered prefrontal function?
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Is better preservation of eccentric strength after stroke due to altered prefrontal function? / Hedlund, Mattias; Lindström, Britta; Sojka, Peter; Lundström, Ronnie; Boraxbekk, Carl Johan.
I: Neurocase, Bind 22, Nr. 2, 03.03.2016, s. 229-242.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Is better preservation of eccentric strength after stroke due to altered prefrontal function?
AU - Hedlund, Mattias
AU - Lindström, Britta
AU - Sojka, Peter
AU - Lundström, Ronnie
AU - Boraxbekk, Carl Johan
N1 - Publisher Copyright: © 2016 Taylor & Francis.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - Ventrolateral prefrontal cortex (VLPFC) is part of a network that exerts inhibitory control over the motor cortex (MC). Recently, we demonstrated that VLPFC was more activated during imagined maximum eccentric than during imagined concentric contractions in healthy participants. This was accompanied with lower activation levels within motor regions during imagined eccentric contractions. The aim was to test a novel hypothesis of an involvement of VLPFC in contraction mode-specific modulation of force. Functional magnetic resonance imaging was used to examine differences in VLPFC and motor regions during the concentric and the eccentric phases of imagined maximum contractions in a selected sample of subjects with stroke (n = 4). The subjects were included as they exhibited disturbed modulation of force. The previously demonstrated pattern within VLPFC was evident only on the contralesional hemisphere. On the ipsilesional hemisphere, the recruitment in VLPFC was similar for both modes of contractions. The findings support a hypothesis of the involvement of VLPFC in contraction mode-specific modulation of maximum force production. A disturbance of this system might underlie the lack of contraction mode-specific modulation commonly found among stroke subjects, often expressed as an increased ratio between eccentric and concentric strength.
AB - Ventrolateral prefrontal cortex (VLPFC) is part of a network that exerts inhibitory control over the motor cortex (MC). Recently, we demonstrated that VLPFC was more activated during imagined maximum eccentric than during imagined concentric contractions in healthy participants. This was accompanied with lower activation levels within motor regions during imagined eccentric contractions. The aim was to test a novel hypothesis of an involvement of VLPFC in contraction mode-specific modulation of force. Functional magnetic resonance imaging was used to examine differences in VLPFC and motor regions during the concentric and the eccentric phases of imagined maximum contractions in a selected sample of subjects with stroke (n = 4). The subjects were included as they exhibited disturbed modulation of force. The previously demonstrated pattern within VLPFC was evident only on the contralesional hemisphere. On the ipsilesional hemisphere, the recruitment in VLPFC was similar for both modes of contractions. The findings support a hypothesis of the involvement of VLPFC in contraction mode-specific modulation of maximum force production. A disturbance of this system might underlie the lack of contraction mode-specific modulation commonly found among stroke subjects, often expressed as an increased ratio between eccentric and concentric strength.
KW - concentric
KW - eccentric
KW - fMRI
KW - inhibition
KW - Motor imagery
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84956648177&partnerID=8YFLogxK
U2 - 10.1080/13554794.2015.1130232
DO - 10.1080/13554794.2015.1130232
M3 - Journal article
C2 - 26750576
AN - SCOPUS:84956648177
VL - 22
SP - 229
EP - 242
JO - Neurocase
JF - Neurocase
SN - 1355-4794
IS - 2
ER -
ID: 339142481