Ion-driven rotary membrane motors: From structure to function
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Ion-driven rotary membrane motors : From structure to function. / Martin, Freddie J. O.; Santiveri, Mònica; Hu, Haidai; Taylor, Nicholas M. I.
I: Current Opinion in Structural Biology, Bind 88, 102884, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ion-driven rotary membrane motors
T2 - From structure to function
AU - Martin, Freddie J. O.
AU - Santiveri, Mònica
AU - Hu, Haidai
AU - Taylor, Nicholas M. I.
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - Ion-driven membrane motors, essential across all domains of life, convert a gradient of ions across a membrane into rotational energy, facilitating diverse biological processes including ATP synthesis, substrate transport, and bacterial locomotion. Herein, we highlight recent structural advances in the understanding of two classes of ion-driven membrane motors: rotary ATPases and 5:2 motors. The recent structure of the human F-type ATP synthase is emphasised along with the gained structural insight into clinically relevant mutations. Furthermore, we highlight the diverse roles of 5:2 motors and recent mechanistic understanding gained through the resolution of ions in the structure of a sodium-driven motor, combining insights into potential unifying mechanisms of ion selectivity and rotational torque generation in the context of their function as part of complex biological systems.
AB - Ion-driven membrane motors, essential across all domains of life, convert a gradient of ions across a membrane into rotational energy, facilitating diverse biological processes including ATP synthesis, substrate transport, and bacterial locomotion. Herein, we highlight recent structural advances in the understanding of two classes of ion-driven membrane motors: rotary ATPases and 5:2 motors. The recent structure of the human F-type ATP synthase is emphasised along with the gained structural insight into clinically relevant mutations. Furthermore, we highlight the diverse roles of 5:2 motors and recent mechanistic understanding gained through the resolution of ions in the structure of a sodium-driven motor, combining insights into potential unifying mechanisms of ion selectivity and rotational torque generation in the context of their function as part of complex biological systems.
U2 - 10.1016/j.sbi.2024.102884
DO - 10.1016/j.sbi.2024.102884
M3 - Review
C2 - 39053417
AN - SCOPUS:85199199949
VL - 88
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
M1 - 102884
ER -
ID: 399963059