TY - JOUR

T1 - Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals

AU - Boraxbekk, C. J.

AU - Ames, David

AU - Kochan, Nicole A.

AU - Lee, Teresa

AU - Thalamuthu, Anbupalam

AU - Wen, Wei

AU - Armstrong, Nicola J.

AU - Kwok, John B.J.

AU - Schofield, Peter R.

AU - Reppermund, Simone

AU - Wright, Margaret J.

AU - Trollor, Julian N.

AU - Brodaty, Henry

AU - Sachdev, Perminder

AU - Mather, Karen A.

N1 - Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015

Y1 - 2015

N2 - The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65-90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.

AB - The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65-90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.

KW - CLSTN2

KW - Episodic memory

KW - Gene-gene interactions

KW - Hippocampus

KW - KIBRA

U2 - 10.1016/j.neuropsychologia.2015.09.031

DO - 10.1016/j.neuropsychologia.2015.09.031

M3 - Journal article

C2 - 26415670

AN - SCOPUS:84943171516

VL - 78

SP - 10

EP - 17

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

ER -