Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis

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Standard

Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis. / Abay-Nørgaard, Steffen; Tapia, Marta Cecylia; Zeijdner, Mandoh; Kim, Jeonghwan Henry; Won, Kyoung Jae; Porse, Bo; Salcini, Anna Elisabetta.

I: Life Science Alliance, Bind 6, Nr. 8, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Abay-Nørgaard, S, Tapia, MC, Zeijdner, M, Kim, JH, Won, KJ, Porse, B & Salcini, AE 2023, 'Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis', Life Science Alliance, bind 6, nr. 8. https://doi.org/10.26508/lsa.202301970

APA

Abay-Nørgaard, S., Tapia, M. C., Zeijdner, M., Kim, J. H., Won, K. J., Porse, B., & Salcini, A. E. (2023). Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis. Life Science Alliance, 6(8). https://doi.org/10.26508/lsa.202301970

Vancouver

Abay-Nørgaard S, Tapia MC, Zeijdner M, Kim JH, Won KJ, Porse B o.a. Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis. Life Science Alliance. 2023;6(8). https://doi.org/10.26508/lsa.202301970

Author

Abay-Nørgaard, Steffen ; Tapia, Marta Cecylia ; Zeijdner, Mandoh ; Kim, Jeonghwan Henry ; Won, Kyoung Jae ; Porse, Bo ; Salcini, Anna Elisabetta. / Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis. I: Life Science Alliance. 2023 ; Bind 6, Nr. 8.

Bibtex

@article{1c75d28f8f5d40bab777d2beff73aa56,

title = "Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis",

abstract = "Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis. ",

keywords = "Animals, Methylation, Caenorhabditis elegans/genetics, Epigenome, Epigenomics, Homeostasis/genetics",

author = "Steffen Abay-N{\o}rgaard and Tapia, {Marta Cecylia} and Mandoh Zeijdner and Kim, {Jeonghwan Henry} and Won, {Kyoung Jae} and Bo Porse and Salcini, {Anna Elisabetta}",

note = "{\textcopyright} 2023 Abay-N{\o}rgaard et al.",

year = "2023",

doi = "10.26508/lsa.202301970",

language = "English",

volume = "6",

journal = "Life Science Alliance",

issn = "2575-1077",

publisher = "Life Science Alliance",

number = "8",

}

RIS

TY - JOUR

T1 - Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis

AU - Abay-Nørgaard, Steffen

AU - Tapia, Marta Cecylia

AU - Zeijdner, Mandoh

AU - Kim, Jeonghwan Henry

AU - Won, Kyoung Jae

AU - Porse, Bo

AU - Salcini, Anna Elisabetta

PY - 2023

Y1 - 2023

N2 - Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis.

AB - Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis.

KW - Animals

KW - Methylation

KW - Caenorhabditis elegans/genetics

KW - Epigenome

KW - Epigenomics

KW - Homeostasis/genetics

U2 - 10.26508/lsa.202301970

DO - 10.26508/lsa.202301970

M3 - Journal article

C2 - 37225426

VL - 6

JO - Life Science Alliance

JF - Life Science Alliance

SN - 2575-1077

IS - 8

ER -

ID: 348140274