Intense pulsed light treatment for hidradenitis suppurativa: a within-person randomized controlled trial
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Intense pulsed light treatment for hidradenitis suppurativa : a within-person randomized controlled trial. / Andersen, Pernille Lindsø; Riis, Peter Theut; Thorlacius, Linnea; Sigsgaard, Viktoria; Nielsen, Christina Wilken; Chafranska, Lana; Westergaard, Christine; Jemec, Gregor Borut; Saunte, Ditte Marie.
I: European journal of dermatology : EJD, Bind 30, Nr. 6, 2020, s. 723-729.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Intense pulsed light treatment for hidradenitis suppurativa
T2 - a within-person randomized controlled trial
AU - Andersen, Pernille Lindsø
AU - Riis, Peter Theut
AU - Thorlacius, Linnea
AU - Sigsgaard, Viktoria
AU - Nielsen, Christina Wilken
AU - Chafranska, Lana
AU - Westergaard, Christine
AU - Jemec, Gregor Borut
AU - Saunte, Ditte Marie
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the intertriginous areas. HS affects hair follicles causing perifollicular inflammation, resulting in the formation of nodules and painful abscesses. Intense pulsed light (IPL) uses selective photothermolysis to destroy the hair follicles.OBJECTIVES: To evaluate the effect of IPL hair removal as treatment for mild-to-moderate HS.MATERIALS & METHODS: We conducted a single-blinded, clinical randomized trial with patients with Hurley Stage I-II. Patients with symmetrical disease were randomized to monthly unilateral treatment of the axilla or groin. The contralateral side served as internal control. Concomitant treatment modalities for HS were not permitted throughout the study. Efficacy was assessed using Hidradenitis Suppurativa Clinical Response (HiSCR), modified Sartorius score (MSS) and patient-reported outcomes.RESULTS: A total of 17 patients completed the trial and were included in the analysis. HiSCR was not evaluated in patients without abscesses or inflammatory nodules pre-treatment. HiSCR was insignificantly different between the intervention side (8/12) and control side (4/10), P=0.467. There was, however, a significant reduction in regional MSS on the intervention side with a median score decreasing from 8.5 (IQR: 6.3-13.5) to 4.5 (IQR 1.8-8.0) post-treatment, P=0.006, and an insignificant score reduction in the control side from 6.0 (IQR: 4.5-8.3) to 5.0 (IQR: 2.5-9.0), post-treatment P=0.492.CONCLUSION: IPL hair removal resulted in a significant reduction on MSS on the treated area with no significant reduction on the control side. Our study suggests that IPL may be an effective treatment for mild-to-moderate HS.
AB - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the intertriginous areas. HS affects hair follicles causing perifollicular inflammation, resulting in the formation of nodules and painful abscesses. Intense pulsed light (IPL) uses selective photothermolysis to destroy the hair follicles.OBJECTIVES: To evaluate the effect of IPL hair removal as treatment for mild-to-moderate HS.MATERIALS & METHODS: We conducted a single-blinded, clinical randomized trial with patients with Hurley Stage I-II. Patients with symmetrical disease were randomized to monthly unilateral treatment of the axilla or groin. The contralateral side served as internal control. Concomitant treatment modalities for HS were not permitted throughout the study. Efficacy was assessed using Hidradenitis Suppurativa Clinical Response (HiSCR), modified Sartorius score (MSS) and patient-reported outcomes.RESULTS: A total of 17 patients completed the trial and were included in the analysis. HiSCR was not evaluated in patients without abscesses or inflammatory nodules pre-treatment. HiSCR was insignificantly different between the intervention side (8/12) and control side (4/10), P=0.467. There was, however, a significant reduction in regional MSS on the intervention side with a median score decreasing from 8.5 (IQR: 6.3-13.5) to 4.5 (IQR 1.8-8.0) post-treatment, P=0.006, and an insignificant score reduction in the control side from 6.0 (IQR: 4.5-8.3) to 5.0 (IQR: 2.5-9.0), post-treatment P=0.492.CONCLUSION: IPL hair removal resulted in a significant reduction on MSS on the treated area with no significant reduction on the control side. Our study suggests that IPL may be an effective treatment for mild-to-moderate HS.
KW - Adult
KW - Female
KW - Hidradenitis Suppurativa/therapy
KW - Humans
KW - Intense Pulsed Light Therapy
KW - Male
KW - Middle Aged
KW - Single-Blind Method
U2 - 10.1684/ejd.2020.3920
DO - 10.1684/ejd.2020.3920
M3 - Tidsskriftartikel
C2 - 33300880
VL - 30
SP - 723
EP - 729
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 6
ER -
ID: 260761426