Intact mammalian cell function on semi-conductor nanowire arrays: new perspectives for cell-based biosensing: New Perspectives for Cell-Based

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Nanowires (NWs) are attracting more and more interest due to their potential cellular applications, such as delivery of compounds or sensing platforms. Arrays of vertical indium-arsenide (InAs) NWs are interfaced with human embryonic kidney cells and rat embryonic dorsal root ganglion neurons. A selection of critical cell functions and pathways are shown not to be impaired, including cell adhesion, membrane integrity, intracellular enzyme activity, DNA uptake, cytosolic and membrane protein expression, and the neuronal maturation pathway. The results demonstrate the low invasiveness of InAs NW arrays, which, combined with the unique physical properties of InAs, open up their potential for cellular investigations.
Udgave nummer6
Sider (fra-til)640-647
Antal sider8
StatusUdgivet - 7 mar. 2011

ID: 33826061