Insulin-like growth factor I and anthropometric parameters in a Danish population
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Insulin-like growth factor I and anthropometric parameters in a Danish population. / Friedrich, N; Jørgensen, Torben; Juul, A; Spielhagen, C; Nauck, M; Wallaschofski, H; Linneberg, A.
I: Experimental and Clinical Endocrinology and Diabetes, Bind 120, Nr. 3, 2012, s. 171-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Insulin-like growth factor I and anthropometric parameters in a Danish population
AU - Friedrich, N
AU - Jørgensen, Torben
AU - Juul, A
AU - Spielhagen, C
AU - Nauck, M
AU - Wallaschofski, H
AU - Linneberg, A
N1 - © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.
PY - 2012
Y1 - 2012
N2 - During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.
AB - During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.
U2 - 10.1055/s-0031-1301289
DO - 10.1055/s-0031-1301289
M3 - Journal article
C2 - 22402920
VL - 120
SP - 171
EP - 174
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
SN - 0947-7349
IS - 3
ER -
ID: 40167097